CXCR4 Monoclonal Antibody (12G5), PE | Invitrogen MHCXCR404 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CXCR4 Monoclonal Antibody (12G5), PE

catalog :

MHCXCR404

quantity :

500 µL

price :

US 497.00

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

12G5

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; fig 2	Smith B, Stanford E, Sherr D, Murphy G. Genome Editing of the CYP1A1 Locus in iPSCs as a Platform to Map AHR Expression throughout Human Development. Stem Cells Int. 2016;2016:2574152 pubmed publisher
immunohistochemistry; human; tbl 4	Leung A, Murphy G. Multisystemic Disease Modeling of Liver-Derived Protein Folding Disorders Using Induced Pluripotent Stem Cells (iPSCs). Methods Mol Biol. 2016;1353:261-70 pubmed publisher
flow cytometry; human; fig 1	Perdomo Arciniegas A, Vernot J. Co-culture of hematopoietic stem cells with mesenchymal stem cells increases VCAM-1-dependent migration of primitive hematopoietic stem cells. Int J Hematol. 2011;94:525-32 pubmed publisher
immunohistochemistry - paraffin section; human; fig 4	Mortezavi A, Hermanns T, Seifert H, Baumgartner M, Provenzano M, Sulser T, et al. KPNA2 expression is an independent adverse predictor of biochemical recurrence after radical prostatectomy. Clin Cancer Res. 2011;17:1111-21 pubmed publisher
flow cytometry; human	Liu Z, Tabakman S, Chen Z, Dai H. Preparation of carbon nanotube bioconjugates for biomedical applications. Nat Protoc. 2009;4:1372-82 pubmed publisher
	Kr xfc ger J, Fischer A, Breunig M, Allg xf6 wer C, Schulte L, Merkle J, et al. DNA methylation-associated allelic inactivation regulates Keratin 19 gene expression during pancreatic development and carcinogenesis. J Pathol. 2023;261:139-155 pubmed publisher
	Werder R, Liu T, Abo K, Lindstrom Vautrin J, Villacorta Martin C, Huang J, et al. CRISPR interference interrogation of COPD GWAS genes reveals the functional significance of desmoplakin in iPSC-derived alveolar epithelial cells. Sci Adv. 2022;8:eabo6566 pubmed publisher
	Kr xfc ger J, Breunig M, Pasquini L, Morawe M, Gro xdf A, Arnold F, et al. Functional Genomic Screening in Human Pluripotent Stem Cells Reveals New Roadblocks in Early Pancreatic Endoderm Formation. Cells. 2022;11: pubmed publisher
	Breunig M, Merkle J, Melzer M, Heller S, Seufferlein T, Meier M, et al. Differentiation of human pluripotent stem cells into pancreatic duct-like organoids. STAR Protoc. 2021;2:100913 pubmed publisher
	Heller S, Li Z, Lin Q, Geusz R, Breunig M, Hohwieler M, et al. Transcriptional changes and the role of ONECUT1 in hPSC pancreatic differentiation. Commun Biol. 2021;4:1298 pubmed publisher
	Merkle J, Breunig M, Schmid M, Allgöwer C, Krüger J, Melzer M, et al. CDKN2A-Mutated Pancreatic Ductal Organoids from Induced Pluripotent Stem Cells to Model a Cancer Predisposition Syndrome. Cancers (Basel). 2021;13: pubmed publisher
	Werder R, Kaserman J, Packer M, Lindstrom Vautrin J, Villacorta Martin C, Young L, et al. Adenine base editing reduces misfolded protein accumulation and toxicity in alpha-1 antitrypsin deficient patient iPSC-hepatocytes. Mol Ther. 2021;29:3219-3229 pubmed publisher
	Breunig M, Merkle J, Wagner M, Melzer M, Barth T, Engleitner T, et al. Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells. Cell Stem Cell. 2021;28:1105-1124.e19 pubmed publisher
	Mithal A, Capilla A, Heinze D, Berical A, Villacorta Martin C, Vedaie M, et al. Generation of mesenchyme free intestinal organoids from human induced pluripotent stem cells. Nat Commun. 2020;11:215 pubmed publisher
	Nair R, Madiwale S, Saini D. Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4. NPJ Aging Mech Dis. 2018;4:9 pubmed publisher
	Huang S, Green M, de Carvalho A, Mumau M, Chen Y, D Souza S, et al. The in vitro generation of lung and airway progenitor cells from human pluripotent stem cells. Nat Protoc. 2015;10:413-25 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CXCR4 Monoclonal Antibody (12G5), PE

Catalog # :

MHCXCR404

Quantity :

500 µL

Price :

US 497.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

12G5

Isotype :

IgG2a, kappa

Storage :

4° C, store in dark

Description :

CXCR4 (Fusin, LESTR, HUMSTR) is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains, and functions as a co-receptor for X4 HIV-1 entry into CD4+ cells. CXCR4 has been proved to be the co-receptor for HIV-2's binding to CD4 through envelope glycoprotein gp 120 and promotes Env-mediated fusion of the virus. In other cases, CXCR4 can even function as the only receptor for HIV-2's binding to the CD4 host cells. CXCR4 is the receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation. CXCR4 acts as a receptor for extracellular ubiquitin; leading to enhanced intracellular calcium ions and reduced cellular cAMP levels. Also, CXCR4 is involved in hematopoiesis and in cardiac ventricular septum formation, and plays an essential role in vascularization of the gastrointestinal tract, probably by regulating vascular branching and/or remodeling processes in endothelial cells. In the CNS, CXCR4 could mediate hippocampal-neuron survival and is involved in cerebellar development. CXCR4 binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV biding sites.

Immunogen :

SIV-infected SupT1 cells injected into Balb/c mice

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

b2b220Clo; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD antigen CD184; CD184; CD184 antigen; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor; chemokine receptor (LCR1); chemokine receptor 4; chemokine receptor CXCR4; Cmkar4; CXC; CXC chemokine receptor; C-X-C chemokine receptor type 4; CXC motif chemokine; C-X-C motif chemokine receptor 4; CXCR4; CXC-R4; CXCR-4; D2S201E; FB22; Fusin; HM89; HSY3RR; HUMSTR; LAP3; LAP-3; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; lipopolysaccharide-associated protein 3; LPS-associated protein 3; neuropeptide Y receptor Y3; neuropeptide Y3 receptor; NPY3R; NPYR; NPYRL; NPYY3R; PB-CKR; PBSF/SDF-1; pre-B-cell-derived chemokine receptor; SDF-1 receptor; Sdf1r; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; stromal cell-derived factor 1 receptor; WHIM; WHIMS

more info or order :

Invitrogen product webpage