CD86 Monoclonal Antibody (BU63), FITC | Invitrogen MHCD8601 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD86 Monoclonal Antibody (BU63), FITC

catalog :

MHCD8601

quantity :

500 uL

price :

US 368.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

BU63

reactivity :

human

application :

western blot, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...	Baghel K, Tewari B, Shrivastava R, Malik S, Lone M, Jain N, et al. Macrophages promote matrix protrusive and invasive function of breast cancer cells via MIP-1? dependent upregulation of MYO3A gene in breast cancer cells. Oncoimmunology. 2016;5:e1196299 pubmed publisher
flow cytometry; human; tbl 2 immunocytochemistry; human; fig 2h	Sandilands G, McCrae J, Hill K, Perry M, Baxter D. Major histocompatibility complex class II (DR) antigen and costimulatory molecules on in vitro and in vivo activated human polymorphonuclear neutrophils. Immunology. 2006;119:562-71 pubmed
flow cytometry; human; tbl 1	McIntosh K, Zvonic S, Garrett S, Mitchell J, Floyd Z, Hammill L, et al. The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells. 2006;24:1246-53 pubmed
flow cytometry; human; 3.3 ug/ml	McIlroy D, Tanguy Royer S, Le Meur N, Guisle I, Royer P, Léger J, et al. Profiling dendritic cell maturation with dedicated microarrays. J Leukoc Biol. 2005;78:794-803 pubmed
flow cytometry; human	Zingoni A, Sornasse T, Cocks B, Tanaka Y, Santoni A, Lanier L. Cross-talk between activated human NK cells and CD4+ T cells via OX40-OX40 ligand interactions. J Immunol. 2004;173:3716-24 pubmed
flow cytometry; human	Hertel L, Lacaille V, Strobl H, Mellins E, Mocarski E. Susceptibility of immature and mature Langerhans cell-type dendritic cells to infection and immunomodulation by human cytomegalovirus. J Virol. 2003;77:7563-74 pubmed
flow cytometry; human; fig 1	Vasu C, Wang A, Gorla S, Kaithamana S, Prabhakar B, Holterman M. CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int Immunol. 2003;15:167-75 pubmed
flow cytometry; human	Longoni D, D Amico G, Gaipa G, Bernasconi S, Vulcano M, Onnis P, et al. Commitment of juvenile myelo-monocytic (JMML) leukemic cells to spontaneously differentiate into dendritic cells. Hematol J. 2002;3:302-10 pubmed
flow cytometry; human	Todisco E, Gaipa G, Biagi E, Bonamino M, Gramigna R, Introna M, et al. CD40 ligand-stimulated B cell precursor leukemic cells elicit interferon-gamma production by autologous bone marrow T cells in childhood acute lymphoblastic leukemia. Leukemia. 2002;16:2046-54 pubmed
flow cytometry; human; fig 5a	Ng W, Duggan P, Ponchel F, Matarese G, Lombardi G, Edwards A, et al. Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells. Blood. 2001;98:2736-44 pubmed
	Guan Y, Chen Q, Xu J, Chen B, Ou B, Liu T, et al. The anti-inflammatory effects of mesenchymal stem cells attenuate diffuse pulmonary hemorrhage. Biotechnol J. 2024;19:e2200632 pubmed publisher
	Zhou J, Wang H, Shu T, Wang J, Yang W, Li J, et al. Myeloid-intrinsic cell cycle-related kinase drives immunosuppression to promote tumorigenesis. iScience. 2023;26:107626 pubmed publisher
	Peng H, Lv Y, Li C, Cheng Z, He S, Wang C, et al. Cathepsin S inhibition in dendritic cells prevents Th17 cell differentiation in perivascular adipose tissues following vascular injury in diabetic rats. J Biochem Mol Toxicol. 2023;37:e23419 pubmed publisher
	Zhao X, Qu J, Liu X, Wang J, Ma X, Zhao X, et al. Baicalein suppress EMT of breast cancer by mediating tumor-associated macrophages polarization. Am J Cancer Res. 2018;8:1528-1540 pubmed
	Parker D, Cohen T, Alhede M, Harfenist B, Martin F, Prince A. Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol. 2012;46:6-13 pubmed publisher
	Guest C, Deszo E, Hartman M, York J, Kelley K, Freund G. Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile. PLoS ONE. 2008;3:e1606 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD86 Monoclonal Antibody (BU63), FITC

Catalog # :

MHCD8601

Quantity :

500 uL

Price :

US 368.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

BU63

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation in the absence of sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD80 appears to play a role distinct from CD80 in T helper cell differentiation. CD86 is a type I membrane protein that is a member of the immunoglobulin superfamily. The CD86 protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in two transcript variants encoding different isoforms of CD86. Additional transcript variants have been described for CD86, but their full-length sequences have not been determined. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.

Immunogen :

B-lymphoblastoid cell line ARH 77

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

activation B7-2 antigen; B lymphocyte activation antigen B72; B7; B7.2; B70; B7-2; B-lymphocyte activation antigen B7-2; BU63; CD28 antigen ligand 2; Cd28l2; CD28LG2; CD86; CD86 antigen; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 antigen precursor; CD86 molecule; CLS1; CTLA-4 counter-receptor B7.2; early T cell costimulatory molecule-1; early T-cell costimulatory molecule 1; Early T-cell co-stimulatory molecule 1; ETC-1; FUN-1; LAB72; Ly58; Ly-58; MB7; MB7-2; membrane glycoprotein; MGC34413; T-lymphocyte activation antigen CD86; TS/A-2

more info or order :

Invitrogen product webpage