product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD56 Monoclonal Antibody (MEM-188)
catalog :
MHCD5600
quantity :
500 µL
price :
US 233.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MEM-188
reactivity :
human, mouse, chicken, rhesus macaque
application :
immunoprecipitation, flow cytometry, blocking or activating experiments
more info or order :
Invitrogen product webpage
citations: 25
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig s5a
Galperin M, Farenc C, Mukhopadhyay M, Jayasinghe D, Decroos A, Benati D, et al. CD4+ T cell-mediated HLA class II cross-restriction in HIV controllers. Sci Immunol. 2018;3: pubmed publisher
  • flow cytometry; human; loading ...; fig 3a
Kim J, Kwon C, Joh J, Sinn D, Choi G, Park J, et al. Differences in Peripheral Blood Lymphocytes between Brand-Name and Generic Tacrolimus Used in Stable Liver Transplant Recipients. Med Princ Pract. 2017;26:221-228 pubmed publisher
  • flow cytometry; human; 1:5; loading ...
Lu X, Chen Q, Rong Y, Yang G, Li C, Xu N, et al. LECT2 drives haematopoietic stem cell expansion and mobilization via regulating the macrophages and osteolineage cells. Nat Commun. 2016;7:12719 pubmed publisher
  • flow cytometry; rhesus macaque; loading ...; fig 4a
DeGottardi M, Okoye A, Vaidya M, Talla A, Konfe A, Reyes M, et al. Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques. J Immunol. 2016;197:1183-98 pubmed publisher
  • flow cytometry; human; loading ...; fig 1
Heath J, Newhook N, Comeau E, Gallant M, Fudge N, Grant M. NKG2C(+)CD57(+) Natural Killer Cell Expansion Parallels Cytomegalovirus-Specific CD8(+) T Cell Evolution towards Senescence. J Immunol Res. 2016;2016:7470124 pubmed publisher
  • flow cytometry; mouse; loading ...
Okoye Okafor U, Bartholdy B, Cartier J, Gao E, Pietrak B, Rendina A, et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat Chem Biol. 2015;11:878-86 pubmed publisher
  • flow cytometry; human
Grieco A, Billett H, Green N, Driscoll M, Bouhassira E. Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1. PLoS ONE. 2015;10:e0129431 pubmed publisher
  • flow cytometry; human; loading ...; fig 1
DaFonseca S, Niessl J, Pouvreau S, Wacleche V, Gosselin A, Cleret Buhot A, et al. Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART. Retrovirology. 2015;12:38 pubmed publisher
  • flow cytometry; human; fig 1
Elsner L, Flügge P, Lozano J, Muppala V, Eiz Vesper B, Demiroglu S, et al. The endogenous danger signals HSP70 and MICA cooperate in the activation of cytotoxic effector functions of NK cells. J Cell Mol Med. 2010;14:992-1002 pubmed publisher
  • flow cytometry; human; loading ...; fig 2a
Grahmann P, Braun R. A new protocol for multiple inhalation of IFN-gamma successfully treats MDR-TB: a case study. Int J Tuberc Lung Dis. 2008;12:636-44 pubmed
  • blocking or activating experiments; human; fig 3
Wagner W, Wein F, Roderburg C, Saffrich R, Diehlmann A, Eckstein V, et al. Adhesion of human hematopoietic progenitor cells to mesenchymal stromal cells involves CD44. Cells Tissues Organs. 2008;188:160-9 pubmed
  • flow cytometry; human
Mselle T, Meadows S, Eriksson M, Smith J, SHEN L, Wira C, et al. Unique characteristics of NK cells throughout the human female reproductive tract. Clin Immunol. 2007;124:69-76 pubmed
  • flow cytometry; human
Mageed A, Pietryga D, DeHeer D, West R. Isolation of large numbers of mesenchymal stem cells from the washings of bone marrow collection bags: characterization of fresh mesenchymal stem cells. Transplantation. 2007;83:1019-26 pubmed
  • flow cytometry; human
Eriksson M, Meadows S, Basu S, Mselle T, Wira C, Sentman C. TLRs mediate IFN-gamma production by human uterine NK cells in endometrium. J Immunol. 2006;176:6219-24 pubmed
  • flow cytometry; human; tbl 1
Tan P, Chan C, Xue S, Dong R, Ananthesayanan B, Manunta M, et al. Phenotypic and functional differences between human saphenous vein (HSVEC) and umbilical vein (HUVEC) endothelial cells. Atherosclerosis. 2004;173:171-83 pubmed
  • flow cytometry; human; fig 1
Steinberger P, Majdic O, Derdak S, Pfistershammer K, Kirchberger S, Klauser C, et al. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J Immunol. 2004;172:2352-9 pubmed
  • flow cytometry; human
Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, et al. LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med. 2003;198:1453-62 pubmed
  • flow cytometry; human
Kim C, Johnston B, Butcher E. Trafficking machinery of NKT cells: shared and differential chemokine receptor expression among V alpha 24(+)V beta 11(+) NKT cell subsets with distinct cytokine-producing capacity. Blood. 2002;100:11-6 pubmed
  • immunoprecipitation; chicken; fig 5
Cunningham B, Hemperly J, Murray B, Prediger E, Brackenbury R, Edelman G. Neural cell adhesion molecule: structure, immunoglobulin-like domains, cell surface modulation, and alternative RNA splicing. Science. 1987;236:799-806 pubmed
  • immunoprecipitation; human; fig 1
Lanier L, Testi R, Bindl J, Phillips J. Identity of Leu-19 (CD56) leukocyte differentiation antigen and neural cell adhesion molecule. J Exp Med. 1989;169:2233-8 pubmed
Zhang J, Supakorndej T, Krambs J, Rao M, Abou Ezzi G, Ye R, et al. Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking. J Clin Invest. 2019;129:2920-2931 pubmed publisher
Desimio M, Giuliani E, Ferraro A, Adorno G, Doria M. In Vitro Exposure to Prostratin but Not Bryostatin-1 Improves Natural Killer Cell Functions Including Killing of CD4+ T Cells Harboring Reactivated Human Immunodeficiency Virus. Front Immunol. 2018;9:1514 pubmed publisher
Nouri Shirazi M, Bible B, Zeng M, Tamjidi S, Bossart G. Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Vet Res. 2017;13:78 pubmed publisher
Perdu S, Castellana B, Kim Y, Chan K, DeLuca L, Beristain A. Maternal obesity drives functional alterations in uterine NK cells. JCI Insight. 2016;1:e85560 pubmed publisher
Müller J, Waldmann T, Kruhlak M, Dubois S. Paracrine and transpresentation functions of IL-15 are mediated by diverse splice versions of IL-15R? in human monocytes and dendritic cells. J Biol Chem. 2012;287:40328-38 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD56 Monoclonal Antibody (MEM-188)
Catalog # :
MHCD5600
Quantity :
500 µL
Price :
US 233.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-Dependent
Species :
Human
Clone :
MEM-188
Isotype :
IgG2a, kappa
Storage :
4° C, store in dark
Description :
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein of the immunoglobulin family that serves as an adhesive molecule and is ubiquitously expressed in the nervous system in isoforms ranging from 120-180 kDa. CD56 is found on T cells and NK cells, and is involved in cell migration, axonal growth, pathfinding and synaptic plasticity. Polysialic modification results in reduction of CD56-mediated cell adhesion. Through its extracellular region, CD56 mediates homophilic and heterophilic interactions by binding extracellular matrix components such as laminin and integrins. CD56 is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma. Further, CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and ovarian granulosa cell tumors. Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
Immunogen :
Human CD56
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent
Aliases :
adhesion molecule; antigen recognized by monoclonal antibody 5.1H11; Cd56; CD-56; CD56 120 kDa GPI-linked isoform; CD56 140 kDa isoform; CD56 140 kDa VASE isoform; E NCAM; E-NCAM; MSK39; N CAM1; NCAM; N-CAM; Ncam1; N-CAM-1; NCAM-1; NCAMC; NCAM-C; neural cell adhesion molecule; Neural cell adhesion molecule 1; neural cell adhesion molecule, NCAM; sCD56; sNCAM; soluble CD56; soluble NCAM
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA