CD45 Monoclonal Antibody (HI30), Alexa Fluor 488 | Invitrogen MHCD4520 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45 Monoclonal Antibody (HI30), Alexa Fluor 488

catalog :

MHCD4520

quantity :

500 uL

price :

US 508.00

clonality :

monoclonal

host :

mouse

conjugate :

AF488

clone name :

HI30

reactivity :

human

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 16

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human	Quarta M, Brett J, DiMarco R, de Morrée A, Boutet S, Chacon R, et al. An artificial niche preserves the quiescence of muscle stem cells and enhances their therapeutic efficacy. Nat Biotechnol. 2016;34:752-9 pubmed publisher
immunocytochemistry; human; loading ...; fig 6b	Shaw Bagnall J, Byun S, Miyamoto D, Kang J, Maheswaran S, Stott S, et al. Deformability-based cell selection with downstream immunofluorescence analysis. Integr Biol (Camb). 2016;8:654-64 pubmed publisher
flow cytometry; human; fig 5	Yawata N, Selva K, Liu Y, Tan K, Lee A, Siak J, et al. Dynamic change in natural killer cell type in the human ocular mucosa in situ as means of immune evasion by adenovirus infection. Mucosal Immunol. 2016;9:159-70 pubmed publisher
flow cytometry; human; fig 3	Mokry J, Soukup T, Micuda S, Karbanova J, Visek B, Brcakova E, et al. Telomere attrition occurs during ex vivo expansion of human dental pulp stem cells. J Biomed Biotechnol. 2010;2010:673513 pubmed publisher
	Benjamin D, Both P, Benjamin J, Nutter C, Tan J, Kang J, et al. Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling. Cell Metab. 2022;34:902-918.e6 pubmed publisher
	Wei X, Xiang Y, Peters D, Marius C, Sun T, Shan R, et al. HiCAR is a robust and sensitive method to analyze open-chromatin-associated genome organization. Mol Cell. 2022;82:1225-1238.e6 pubmed publisher
	Cheng K, Pan R, Pan H, Li B, Meena S, Xing H, et al. ALICE: a hybrid AI paradigm with enhanced connectivity and cybersecurity for a serendipitous encounter with circulating hybrid cells. Theranostics. 2020;10:11026-11048 pubmed publisher
	Labib M, Wang Z, Ahmed S, Mohamadi R, Duong B, Green B, et al. Tracking the expression of therapeutic protein targets in rare cells by antibody-mediated nanoparticle labelling and magnetic sorting. Nat Biomed Eng. 2020;: pubmed publisher
	Sarkar T, Quarta M, Mukherjee S, Colville A, Paine P, Doan L, et al. Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells. Nat Commun. 2020;11:1545 pubmed publisher
	Sun Y, Wu G, Cheng K, Chen A, Neoh K, Chen S, et al. CTC phenotyping for a preoperative assessment of tumor metastasis and overall survival of pancreatic ductal adenocarcinoma patients. EBioMedicine. 2019;46:133-149 pubmed publisher
	Lin T, Chen S, Chuang Y, Lan M, Chuang J, Wang P, et al. Mitochondrial Transfer of Wharton's Jelly Mesenchymal Stem Cells Eliminates Mutation Burden and Rescues Mitochondrial Bioenergetics in Rotenone-Stressed MELAS Fibroblasts. Oxid Med Cell Longev. 2019;2019:9537504 pubmed publisher
	Larmour L, Cousins F, Teague J, Deane J, Jobling T, Gargett C. A patient derived xenograft model of cervical cancer and cervical dysplasia. PLoS ONE. 2018;13:e0206539 pubmed publisher
	Labib M, Mohamadi R, Poudineh M, Ahmed S, Ivanov I, Huang C, et al. Single-cell mRNA cytometry via sequence-specific nanoparticle clustering and trapping. Nat Chem. 2018;10:489-495 pubmed publisher
	Quarta M, Cromie M, Chacon R, Blonigan J, Garcia V, Akimenko I, et al. Bioengineered constructs combined with exercise enhance stem cell-mediated treatment of volumetric muscle loss. Nat Commun. 2017;8:15613 pubmed publisher
	Poudineh M, Aldridge P, Ahmed S, Green B, Kermanshah L, Nguyen V, et al. Tracking the dynamics of circulating tumour cell phenotypes using nanoparticle-mediated magnetic ranking. Nat Nanotechnol. 2017;12:274-281 pubmed publisher
	Shaw Bagnall J, Byun S, Begum S, Miyamoto D, Hecht V, Maheswaran S, et al. Deformability of Tumor Cells versus Blood Cells. Sci Rep. 2015;5:18542 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45 Monoclonal Antibody (HI30), Alexa Fluor 488

Catalog # :

MHCD4520

Quantity :

500 uL

Price :

US 508.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

HI30

Isotype :

IgG1

Storage :

4 C, store in dark

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Immunogen :

CD45 antigen

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220

more info or order :

Invitrogen product webpage