CD20 Monoclonal Antibody (HI47), FITC | Invitrogen MHCD2001 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD20 Monoclonal Antibody (HI47), FITC

catalog :

MHCD2001

quantity :

0.5 ml

price :

US 254

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

HI47

reactivity :

human, mouse

application :

flow cytometry

citations: 9

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; tbl 2	ChovancovÃ¡ J, Bernard T, StehlÃkovÃ¡ O, SÃ¡lek D, JanÃkovÃ¡ A, Mayer J, et al. Detection of Minimal Residual Disease in Mantle Cell Lymphoma. Establishment of Novel 8-Color Flow Cytometry Approach. Cytometry B Clin Cytom. 2014;: pubmed publisher
flow cytometry; human	Giannelli S, Taddeo A, Presicce P, Villa M, Della Bella S. A six-color flow cytometric assay for the analysis of peripheral blood dendritic cells. Cytometry B Clin Cytom. 2008;74:349-55 pubmed publisher
flow cytometry; human; tbl 1	Kolar G, Mehta D, Pelayo R, Capra J. A novel human B cell subpopulation representing the initial germinal center population to express AID. Blood. 2007;109:2545-52 pubmed
flow cytometry; human	Olivier A, Lauret E, Gonin P, Galy A. The Notch ligand delta-1 is a hematopoietic development cofactor for plasmacytoid dendritic cells. Blood. 2006;107:2694-701 pubmed
flow cytometry; mouse; fig 5	Yu D, Dews M, Park A, Tobias J, Thomas Tikhonenko A. Inactivation of Myc in murine two-hit B lymphomas causes dormancy with elevated levels of interleukin 10 receptor and CD20: implications for adjuvant therapies. Cancer Res. 2005;65:5454-61 pubmed
flow cytometry; human; tbl 1	del Giudice I, Matutes E, Morilla R, Morilla A, Owusu Ankomah K, Rafiq F, et al. The diagnostic value of CD123 in B-cell disorders with hairy or villous lymphocytes. Haematologica. 2004;89:303-8 pubmed
flow cytometry; human	Waterfall M, Black A, Riley E. Gammadelta+ T cells preferentially respond to live rather than killed malaria parasites. Infect Immun. 1998;66:2393-8 pubmed
	Sevigny L, Booth B, Rowley K, Leav B, Cheslock P, GARRITY K, et al. Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication. Infect Immun. 2013;81:3992-4000 pubmed publisher
	Smith K, Garman L, Wrammert J, Zheng N, Capra J, Ahmed R, et al. Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen. Nat Protoc. 2009;4:372-84 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD20 Monoclonal Antibody (HI47), FITC

Catalog # :

MHCD2001

Quantity :

0.5 ml

Price :

US 254

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

HI47

Isotype :

IgG3

Storage :

4° C, store in dark

Description :

CD20 is a non-glycosylated surface phosphoprotein that has a molecular weight range of 33-37 kDa depending on the degree of phosphorylation. CD20 is expressed on mature and most malignant B cells, in a subpopulation of T lymphocytes and follicular dendritic cells. CD20 expression on B cells is synchronous with the expression of surface IgM and it regulates transmembrane calcium conductance, cell cycle progression and B-cell proliferation. CD20 is also associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change, and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following monoclonal antibody treatment. Diseases associated with CD20 dysfunction include Ms4a1-related common variable immune deficiency.

Immunogen :

CD20 antigen

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

B1, Bp35, CD20, LEU-16, MGC3969, MS4A1