product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD19 Monoclonal Antibody (SJ25-C1), Pacific Blue
catalog :
MHCD1928
quantity :
500 uL
price :
US 556.00
clonality :
monoclonal
host :
mouse
conjugate :
Pacific Blue
clone name :
SJ25-C1
reactivity :
African green monkey, crab eating macaque, human, rhesus macaque
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 29
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...
Wahid R, Fresnay S, Levine M, Sztein M. Cross-reactive multifunctional CD4+ T cell responses against Salmonella enterica serovars Typhi, Paratyphi A and Paratyphi B in humans following immunization with live oral typhoid vaccine Ty21a. Clin Immunol. 2016;173:87-95 pubmed publisher
  • flow cytometry; human
Ito S, Barrett A, Dutra A, Pak E, Miner S, Keyvanfar K, et al. Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells. Stem Cell Res. 2015;14:95-104 pubmed publisher
  • flow cytometry; human
Ilander M, Kreutzman A, Rohon P, Melo T, Faber E, Porkka K, et al. Enlarged memory T-cell pool and enhanced Th1-type responses in chronic myeloid leukemia patients who have successfully discontinued IFN-? monotherapy. PLoS ONE. 2014;9:e87794 pubmed publisher
  • flow cytometry; human; fig 9
Pala P, Serwanga J, Watera C, Ritchie A, Moodie Z, Wang M, et al. Quantitative and qualitative differences in the T cell response to HIV in uninfected Ugandans exposed or unexposed to HIV-infected partners. J Virol. 2013;87:9053-63 pubmed publisher
  • flow cytometry; human
Ekeruche Makinde J, Clement M, Cole D, Edwards E, Ladell K, Miles J, et al. T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting. J Biol Chem. 2012;287:37269-81 pubmed publisher
  • flow cytometry; human
McArthur M, Sztein M. Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization. PLoS ONE. 2012;7:e38408 pubmed publisher
  • flow cytometry; human; fig 3
Lyke K, Dabo A, Arama C, Daou M, Diarra I, Wang A, et al. Reduced T regulatory cell response during acute Plasmodium falciparum infection in Malian children co-infected with Schistosoma haematobium. PLoS ONE. 2012;7:e31647 pubmed publisher
  • flow cytometry; human; loading ...; fig 2a
Man S, Tucky B, Cotleur A, Drazba J, Takeshita Y, Ransohoff R. CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier. Sci Transl Med. 2012;4:119ra14 pubmed publisher
  • flow cytometry; human; fig 3
Frasca D, Diaz A, Romero M, Phillips M, Mendez N, Landin A, et al. Unique biomarkers for B-cell function predict the serum response to pandemic H1N1 influenza vaccine. Int Immunol. 2012;24:175-82 pubmed publisher
  • flow cytometry; African green monkey; fig 3
Hirao L, Hokey D, Morrow M, Jure Kunkel M, Weiner D. Immune modulation through 4-1BB enhances SIV vaccine protection in non-human primates against SIVmac251 challenge. PLoS ONE. 2011;6:e24250 pubmed publisher
  • flow cytometry; human; fig 8
Clement M, Ladell K, Ekeruche Makinde J, Miles J, Edwards E, Dolton G, et al. Anti-CD8 antibodies can trigger CD8+ T cell effector function in the absence of TCR engagement and improve peptide-MHCI tetramer staining. J Immunol. 2011;187:654-63 pubmed publisher
  • immunocytochemistry; human
Berthoud T, Hamill M, Lillie P, Hwenda L, Collins K, Ewer K, et al. Potent CD8+ T-cell immunogenicity in humans of a novel heterosubtypic influenza A vaccine, MVA-NP+M1. Clin Infect Dis. 2011;52:1-7 pubmed publisher
  • flow cytometry; rhesus macaque
Hokey D, Yan J, Hirao L, Dai A, Boyer J, Jure Kunkel M, et al. CLTA-4 blockade in vivo promotes the generation of short-lived effector CD8 T cells and a more persistent central memory CD4 T cell response. J Med Primatol. 2008;37 Suppl 2:62-8 pubmed publisher
  • flow cytometry; crab eating macaque
  • flow cytometry; rhesus macaque
Hokey D, Johnson F, Smith J, Weber J, Yan J, Hirao L, et al. Activation drives PD-1 expression during vaccine-specific proliferation and following lentiviral infection in macaques. Eur J Immunol. 2008;38:1435-45 pubmed publisher
Aminov S, Giricz O, Melnekoff D, Sica R, Polishchuk V, Papazoglu C, et al. Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency. J Clin Invest. 2024;134: pubmed publisher
Rasooly R, Do P, Hernlem B. Ex Vivo and In Vitro Methods for Detection of Bioactive Staphylococcal Enterotoxins. Methods Mol Biol. 2022;2393:237-255 pubmed publisher
Keeton R, Richardson S, Moyo Gwete T, Hermanus T, Tincho M, Benede N, et al. Prior infection with SARS-CoV-2 boosts and broadens Ad26.COV2.S immunogenicity in a variant-dependent manner. Cell Host Microbe. 2021;29:1611-1619.e5 pubmed publisher
Amor C, Feucht J, Leibold J, Ho Y, Zhu C, Alonso Curbelo D, et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature. 2020;583:127-132 pubmed publisher
Arif S, Gomez Tourino I, Kamra Y, Pujol Autonell I, Hanton E, Tree T, et al. GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells. Diabetologia. 2020;63:1186-1198 pubmed publisher
Hataye J, Casazza J, Best K, Liang C, Immonen T, Ambrozak D, et al. Principles Governing Establishment versus Collapse of HIV-1 Cellular Spread. Cell Host Microbe. 2019;26:748-763.e20 pubmed publisher
Jain P, Tian X, Cordes S, Chen J, Cantilena C, Bradley C, et al. Over-expression of PD-1 Does Not Predict Leukemic Relapse after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2019;25:216-222 pubmed publisher
Ruella M, Xu J, Barrett D, Fraietta J, Reich T, Ambrose D, et al. Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nat Med. 2018;24:1499-1503 pubmed publisher
Dufva O, Kankainen M, Kelkka T, Sekiguchi N, Awad S, Eldfors S, et al. Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. Nat Commun. 2018;9:1567 pubmed publisher
Gomez Tourino I, Kamra Y, Baptista R, Lorenc A, Peakman M. T cell receptor ?-chains display abnormal shortening and repertoire sharing in type 1 diabetes. Nat Commun. 2017;8:1792 pubmed publisher
Douam F, Hrebikova G, Albrecht Y, Sellau J, Sharon Y, Ding Q, et al. Single-cell tracking of flavivirus RNA uncovers species-specific interactions with the immune system dictating disease outcome. Nat Commun. 2017;8:14781 pubmed publisher
Tanko R, Soares A, Müller T, Garrett N, Samsunder N, Abdool Karim Q, et al. Effect of Antiretroviral Therapy on the Memory and Activation Profiles of B Cells in HIV-Infected African Women. J Immunol. 2017;198:1220-1228 pubmed publisher
Wahid R, Fresnay S, Levine M, Sztein M. Immunization with Ty21a live oral typhoid vaccine elicits crossreactive multifunctional CD8+ T-cell responses against Salmonella enterica serovar Typhi, S. Paratyphi A, and S. Paratyphi B in humans. Mucosal Immunol. 2015;8:1349-59 pubmed publisher
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed publisher
Frasca D, Diaz A, Romero M, Landin A, Phillips M, Lechner S, et al. Intrinsic defects in B cell response to seasonal influenza vaccination in elderly humans. Vaccine. 2010;28:8077-84 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD19 Monoclonal Antibody (SJ25-C1), Pacific Blue
Catalog # :
MHCD1928
Quantity :
500 uL
Price :
US 556.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-Dependent
Species :
Human
Clone :
SJ25-C1
Isotype :
IgG1, kappa
Storage :
4 C, store in dark
Description :
CD19 is a member of the immunoglobulin superfamily and has two Ig like domains. The CD19 molecule is expressed on 100% of the peripheral B cells as defined by expression of kappa or lambda light chains. CD19 appears to be expressed on myeloid leukemia cells, particularly those of monocytic lineage. Leukemia phenotype studies have demonstrated that the earliest and broadest B cell restricted antigen is the CD19 antigen. The receptor for CD19 is an important functional regulator of normal and malignant B cell proliferation, and is expressed in all B cell precursor leukemias. Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. CD19 is a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation. Besides being a signal-amplifying coreceptor for the B cell receptor (BCR), CD19 can also signal independently of BCR co-ligation and is a central regulatory component upon which multiple signaling pathways converge. Mutation of the CD19 gene results in hypogammaglobulinemia, whereas CD19 overexpression causes B cell hyperactivity.
Immunogen :
Nalm 1 Human cell line
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent
Aliases :
AW495831; B4; B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; Cd19; CD19 antigen; CD19 molecule; CVID3; differentiation antigen CD19; Leu-12; T-cell surface antigen Leu-12
more info or order :
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA