CD8 Monoclonal Antibody (3B5), PE-Texas Red | Invitrogen MHCD0817 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD8 Monoclonal Antibody (3B5), PE-Texas Red

catalog :

MHCD0817

quantity :

500 uL

price :

US 540.00

clonality :

monoclonal

host :

mouse

conjugate :

PE Texas Red

clone name :

3B5

reactivity :

African green monkey, human, rhesus macaque

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 30

Published Application/Species/Sample/Dilution	Reference
flow cytometry; African green monkey; loading ...; fig 3b	Raehtz K, Barrenas F, Xu C, Busman Sahay K, Valentine A, Law L, et al. African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity. PLoS Pathog. 2020;16:e1008333 pubmed publisher
flow cytometry; human; loading ...; fig 1a	Gabanti E, Bruno F, Scaramuzzi L, Mangione F, Zelini P, Gerna G, et al. Predictive value of human cytomegalovirus (HCMV) T-cell response in the control of HCMV infection by seropositive solid-organ transplant recipients according to different assays and stimuli. New Microbiol. 2016;39:247-258 pubmed
flow cytometry; human; loading ...	Yadav A, Betts M, Collman R. Statin modulation of monocyte phenotype and function: implications for HIV-1-associated neurocognitive disorders. J Neurovirol. 2016;22:584-596 pubmed
flow cytometry; human; fig 2b	Di Meglio P, Villanova F, Navarini A, Mylonas A, Tosi I, Nestle F, et al. Targeting CD8(+) T cells prevents psoriasis development. J Allergy Clin Immunol. 2016;138:274-276.e6 pubmed publisher
flow cytometry; African green monkey; loading ...; fig 6e	He T, Brocca Cofano E, Gillespie D, Xu C, Stock J, Ma D, et al. Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues. J Virol. 2015;89:9616-30 pubmed publisher
flow cytometry; human; fig 5	Li G, Cheng M, Nunoya J, Cheng L, Guo H, Yu H, et al. Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice. PLoS Pathog. 2014;10:e1004291 pubmed publisher
flow cytometry; rhesus macaque	Bukh I, Calcedo R, Roy S, Carnathan D, Grant R, Qin Q, et al. Increased mucosal CD4+ T cell activation in rhesus macaques following vaccination with an adenoviral vector. J Virol. 2014;88:8468-78 pubmed publisher
flow cytometry; human	Qi Y, Operario D, Georas S, Mosmann T. The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin. PLoS ONE. 2012;7:e39072 pubmed publisher
flow cytometry; rhesus macaque; loading ...; fig 2a	Taaffe J, Bosinger S, Del Prete G, Else J, Ratcliffe S, Ward C, et al. CCR5 blockade is well tolerated and induces changes in the tissue distribution of CCR5+ and CD25+ T cells in healthy, SIV-uninfected rhesus macaques. J Med Primatol. 2012;41:24-42 pubmed publisher
flow cytometry; rhesus macaque; 1:500	Das A, Veazey R, Wang X, Lackner A, Xu H, Pahar B. Simian immunodeficiency virus infection in rhesus macaques induces selective tissue specific B cell defects in double positive CD21+CD27+ memory B cells. Clin Immunol. 2011;140:223-8 pubmed publisher
flow cytometry; human; loading ...; fig 1b	Foster B, Foroughi S, Yin Y, Prussin C. Effect of anti-IgE therapy on food allergen specific T cell responses in eosinophil associated gastrointestinal disorders. Clin Mol Allergy. 2011;9:7 pubmed publisher
flow cytometry; human; loading ...	Zhang L, Jiang Q, Li G, Jeffrey J, Kovalev G, Su L. Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2?/?? C?/? mice in vivo. Blood. 2011;117:6184-92 pubmed publisher
flow cytometry; rhesus macaque; fig 4	Das A, Xu H, Wang X, Yau C, Veazey R, Pahar B. Double-positive CD21+CD27+ B cells are highly proliferating memory cells and their distribution differs in mucosal and peripheral tissues. PLoS ONE. 2011;6:e16524 pubmed publisher
flow cytometry; rhesus macaque; fig 1	Mehra S, Pahar B, Dutta N, Conerly C, Philippi Falkenstein K, Alvarez X, et al. Transcriptional reprogramming in nonhuman primate (rhesus macaque) tuberculosis granulomas. PLoS ONE. 2010;5:e12266 pubmed publisher
flow cytometry; rhesus macaque; fig 1	Wang X, Das A, Lackner A, Veazey R, Pahar B. Intestinal double-positive CD4+CD8+ T cells of neonatal rhesus macaques are proliferating, activated memory cells and primary targets for SIVMAC251 infection. Blood. 2008;112:4981-90 pubmed publisher
flow cytometry; rhesus macaque; fig 4	Pahar B, Cantu M, Zhao W, Kuroda M, Veazey R, Montefiori D, et al. Single epitope mucosal vaccine delivered via immuno-stimulating complexes induces low level of immunity against simian-HIV. Vaccine. 2006;24:6839-49 pubmed
flow cytometry; rhesus macaque	Pahar B, Lackner A, Veazey R. Intestinal double-positive CD4+CD8+ T cells are highly activated memory cells with an increased capacity to produce cytokines. Eur J Immunol. 2006;36:583-92 pubmed
flow cytometry; human; fig 1	Loza M, Perussia B. Peripheral immature CD2-/low T cell development from type 2 to type 1 cytokine production. J Immunol. 2002;169:3061-8 pubmed
	Li C, Phoon Y, Karlinsey K, Tian Y, Thapaliya S, Thongkum A, et al. A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients. J Exp Med. 2022;219: pubmed publisher
	Cai F, Chen W, Wu W, Jones J, Choe M, Gohain N, et al. Structural and genetic convergence of HIV-1 neutralizing antibodies in vaccinated non-human primates. PLoS Pathog. 2021;17:e1009624 pubmed publisher
	Nielsen C, Ogbe A, Pedroza Pacheco I, Doeleman S, Chen Y, Silk S, et al. Protein/AS01B vaccination elicits stronger, more Th2-skewed antigen-specific human T follicular helper cell responses than heterologous viral vectors. Cell Rep Med. 2021;2:100207 pubmed publisher
	Kieffer Y, Hocine H, Gentric G, Pelon F, Bernard C, Bourachot B, et al. Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer. Cancer Discov. 2020;10:1330-1351 pubmed publisher
	Han Q, Jones J, Nicely N, Reed R, Shen X, Mansouri K, et al. Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. Nat Commun. 2019;10:2898 pubmed publisher
	Zappasodi R, Budhu S, Hellmann M, Postow M, Senbabaoglu Y, Manne S, et al. Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity. Cancer Cell. 2018;33:1017-1032.e7 pubmed publisher
	Pinna R, Dos Santos A, Perce da Silva D, da Silva L, da Silva R, Alves M, et al. Correlation of APRIL with production of inflammatory cytokines during acute malaria in the Brazilian Amazon. Immun Inflamm Dis. 2018;6:207-220 pubmed publisher
	Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed publisher
	Zhang Z, Cheng L, Zhao J, Li G, Zhang L, Chen W, et al. Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion. J Clin Invest. 2015;125:3692-703 pubmed publisher
	Qu Y, Frazer L, O Connell C, Tarantal A, Andrews C, O Connor S, et al. Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D. Infect Immun. 2015;83:4056-67 pubmed publisher
	Vanderford T, Slichter C, Rogers K, Lawson B, Obaede R, Else J, et al. Treatment of SIV-infected sooty mangabeys with a type-I IFN agonist results in decreased virus replication without inducing hyperimmune activation. Blood. 2012;119:5750-7 pubmed publisher
	Wang X, Xu H, Alvarez X, Pahar B, Moroney Rasmussen T, Lackner A, et al. Distinct expression patterns of CD69 in mucosal and systemic lymphoid tissues in primary SIV infection of rhesus macaques. PLoS ONE. 2011;6:e27207 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD8 Monoclonal Antibody (3B5), PE-Texas Red

Catalog # :

MHCD0817

Quantity :

500 uL

Price :

US 540.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

3B5

Isotype :

IgG2a

Storage :

4 C, store in dark

Description :

Cluster of differentiation 8 (CD8), a type I transmembrane glycoprotein of the immunoglobulin family of receptors, plays an integral role in signal transduction, and T cell differentiation and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8alpha and CD8beta, where it functions as a co-receptor, along with T cell receptor (TCR), for major histocompatibilty complex class I (MHC-I) molecules; whereas its counterpart, CD4, acts as a co-receptor for MHC-II molecules. CD8 exists on the cell surface, where the CD8alpha chain is essential for binding to MHC-I. CD8 is also expressed on a subset of T cells, NK cells, monocytes and dendritic cells as disulfide-linked homodimers of CD8alpha. Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. Once activated, CTLs play a crucial role in the clearance of pathogens and tumor cells. Differentiation of naive CD8+ T cells into CTLs is strongly enhanced by IL-2, IL-12 and TGF-beta1.

Immunogen :

Human CD8

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

BB154331; CD8; CD8 alpha; CD8 alpha chain; CD8 alpha chain precursor; CD8 antigen; CD8 antigen 32 kDa chain; CD8 antigen 37 kDa chain; CD8 antigen alpha polypeptide; CD8 antigen alpha protein; CD8 antigen alpha protein precursor; CD8 antigen alpha-chain; CD8 antigen beta polypeptide; CD8 antigen beta polypeptide precursor; CD8 antigen beta-chain; CD8 antigen, alpha chain; CD8 antigen, alpha polypeptide; CD8 antigen, alpha polypeptide (p32); CD8 antigen, alpha-chain; CD8 antigen, beta chain; CD8 antigen, beta chain 1; CD8 antigen, beta polypeptide; CD8 antigen, beta polypeptide 1 (p37); CD8 antigen, beta-chain; CD8 beta; CD8 beta chain; CD8 beta-2; CD8a; CD8A antigen alpha; CD8a molecule; CD8A; T-cell surface glycoprotein; CD8alpha; CD8B; CD8b antigen; CD8b molecule; CD8b molecule pseudogene; Cd8b1; CD8beta; CD8BP; fCD8; LEU2; Leu-2; Leu2 T-lymphocyte antigen; leu-2a; Ly-2; LY3; Ly-3; Ly-35; Ly-B; Ly-C; Lymphocyte antigen 3; Lyt2; Lyt-2; Lyt-2.1 lymphocyte differentiation antigen (AA at 100); Lyt3; Lyt-3; MAL; membrane glycoprotein; membrane protein; OKT8 T-cell antigen; OX-8 membrane antigen; p32; P37; RHACD8-4; T cell co-receptor; T lymphocyte surface glycoprotein beta chain; T8 T-cell antigen; T-cell antigen Leu2; T-cell membrane glycoprotein Ly-3; T-cell surface glycoprotein; T-cell surface glycoprotein CD8 alpha chain; T-cell surface glycoprotein CD8 beta chain; T-cell surface glycoprotein Lyt-2; T-cell surface glycoprotein Lyt-3; T-cell surface molecule; T-lymphocyte differentiation antigen T8/Leu-2; type I transmembrane glycoprotein

more info or order :

Invitrogen product webpage