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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (S3.5), Pacific Orange
catalog :
MHCD0430
quantity :
500 uL
price :
US 692.00
clonality :
monoclonal
host :
mouse
conjugate :
pacific orange
clone name :
S3.5
reactivity :
African green monkey, human, rhesus macaque
application :
western blot, immunocytochemistry, flow cytometry
more info or order :
Invitrogen product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human
Riou C, Tanko R, Soares A, Masson L, Werner L, Garrett N, et al. Restoration of CD4+ Responses to Copathogens in HIV-Infected Individuals on Antiretroviral Therapy Is Dependent on T Cell Memory Phenotype. J Immunol. 2015;195:2273-2281 pubmed publisher
  • flow cytometry; human
Grieco A, Billett H, Green N, Driscoll M, Bouhassira E. Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1. PLoS ONE. 2015;10:e0129431 pubmed publisher
  • flow cytometry; human
Boer M, Prins C, van Meijgaarden K, van Dissel J, Ottenhoff T, Joosten S. Mycobacterium bovis BCG Vaccination Induces Divergent Proinflammatory or Regulatory T Cell Responses in Adults. Clin Vaccine Immunol. 2015;22:778-88 pubmed publisher
  • flow cytometry; human
  • immunocytochemistry; human
de Carvalho J, de Castro R, da Silva E, Silveira P, da Silva Januário M, Arruda E, et al. Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection. PLoS ONE. 2014;9:e113691 pubmed publisher
  • flow cytometry; human
Pegram H, Purdon T, van Leeuwen D, Curran K, Giralt S, Barker J, et al. IL-12-secreting CD19-targeted cord blood-derived T cells for the immunotherapy of B-cell acute lymphoblastic leukemia. Leukemia. 2015;29:415-22 pubmed publisher
  • flow cytometry; human; fig 1
Wong E, Akilimali N, Govender P, Sullivan Z, Cosgrove C, Pillay M, et al. Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection. PLoS ONE. 2013;8:e83474 pubmed publisher
  • flow cytometry; rhesus macaque; fig 1
  • western blot; rhesus macaque; fig 1
Cornwell W, Lewis M, Fan X, Rappaport J, Rogers T. Effect of chronic morphine administration on circulating T cell population dynamics in rhesus macaques. J Neuroimmunol. 2013;265:43-50 pubmed publisher
  • flow cytometry; human; fig 4
TAN C, Broge T, Seung E, Vrbanac V, Viscidi R, Gordon J, et al. Detection of JC virus-specific immune responses in a novel humanized mouse model. PLoS ONE. 2013;8:e64313 pubmed publisher
  • flow cytometry; human; fig 1
McArthur M, Sztein M. Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans. Clin Immunol. 2013;146:140-52 pubmed publisher
  • flow cytometry; human; fig 1
Wong W, Sigvardsson M, Astrand Grundström I, Hogge D, Larsson J, Qian H, et al. Expression of integrin ?2 receptor in human cord blood CD34+CD38-CD90+ stem cells engrafting long-term in NOD/SCID-IL2R?(c) null mice. Stem Cells. 2013;31:360-71 pubmed publisher
  • flow cytometry; human; tbl 3
Jankowska M, Marszałł M, Debska Slizien A, Carrero J, Lindholm B, Czarnowski W, et al. Vitamin B6 and the immunity in kidney transplant recipients. J Ren Nutr. 2013;23:57-64 pubmed publisher
  • flow cytometry; human; fig 2
Lunemann J, Frey O, Eidner T, Baier M, Roberts S, Sashihara J, et al. Increased frequency of EBV-specific effector memory CD8+ T cells correlates with higher viral load in rheumatoid arthritis. J Immunol. 2008;181:991-1000 pubmed
  • flow cytometry; human; 1:100; fig 1
Schweneker M, Favre D, Martin J, Deeks S, McCune J. HIV-induced changes in T cell signaling pathways. J Immunol. 2008;180:6490-500 pubmed
  • flow cytometry; African green monkey; fig 1
Contamin H, Loizon S, Bourreau E, Michel J, Garraud O, Mercereau Puijalon O, et al. Flow cytometry identification and characterization of mononuclear cell subsets in the neotropical primate Saimiri sciureus (squirrel monkey). J Immunol Methods. 2005;297:61-71 pubmed
  • flow cytometry; human; fig 1
Game D, Hernandez Fuentes M, Chaudhry A, Lechler R. CD4+CD25+ regulatory T cells do not significantly contribute to direct pathway hyporesponsiveness in stable renal transplant patients. J Am Soc Nephrol. 2003;14:1652-61 pubmed
  • flow cytometry; human; fig 1
Roessner K, Wolfe J, Shi C, Sigal L, Huber S, Budd R. High expression of Fas ligand by synovial fluid-derived gamma delta T cells in Lyme arthritis. J Immunol. 2003;170:2702-10 pubmed
  • flow cytometry; human; fig 3
Telford W, Moss M, Morseman J, Allnutt F. Cryptomonad algal phycobiliproteins as fluorochromes for extracellular and intracellular antigen detection by flow cytometry. Cytometry. 2001;44:16-23 pubmed
  • flow cytometry; human
Le Cleach L, Delaire S, Boumsell L, Bagot M, Bourgault Villada I, Bensussan A, et al. Blister fluid T lymphocytes during toxic epidermal necrolysis are functional cytotoxic cells which express human natural killer (NK) inhibitory receptors. Clin Exp Immunol. 2000;119:225-30 pubmed
  • immunocytochemistry; human; fig 2
Yeaman G, Guyre P, Fanger M, Collins J, White H, Rathbun W, et al. Unique CD8+ T cell-rich lymphoid aggregates in human uterine endometrium. J Leukoc Biol. 1997;61:427-35 pubmed
Axelsson Robertson R, Ju J, Kim H, Zumla A, Maeurer M. Mycobacterium tuberculosis-specific and MHC class I-restricted CD8+ T-cells exhibit a stem cell precursor-like phenotype in patients with active pulmonary tuberculosis. Int J Infect Dis. 2015;32:13-22 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (S3.5), Pacific Orange
Catalog # :
MHCD0430
Quantity :
500 uL
Price :
US 692.00
Clonality :
Monoclonal
Purity :
purified
Host :
Mouse
Reactivity :
Human
Applications :
Flow Cytometry: Assay-Dependent
Species :
Human
Clone :
S3.5
Isotype :
IgG2a
Storage :
4 C, store in dark
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Immunogen :
Human CD4
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-Dependent
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA