CD45 Monoclonal Antibody (30-F11), Pacific Blue | Invitrogen MCD4528 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45 Monoclonal Antibody (30-F11), Pacific Blue

catalog :

MCD4528

quantity :

1 mL

price :

US 413.00

clonality :

monoclonal

host :

rat

conjugate :

Pacific Blue

clone name :

30-F11

reactivity :

mouse

application :

immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 19

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:100; loading ...; fig 3a	Grol M, Haelterman N, Lim J, Munivez E, Archer M, Hudson D, et al. Tendon and motor phenotypes in the Crtap-/- mouse model of recessive osteogenesis imperfecta. elife. 2021;10: pubmed publisher
flow cytometry; mouse; 1:25; loading ...	Lukjanenko L, Jung M, Hegde N, Perruisseau Carrier C, Migliavacca E, Rozo M, et al. Loss of fibronectin from the aged stem cell niche affects the regenerative capacity of skeletal muscle in mice. Nat Med. 2016;22:897-905 pubmed publisher
flow cytometry; mouse; loading ...; fig s2d	Lal G, Nakayama Y, Sethi A, Singh A, Burrell B, Kulkarni N, et al. Interleukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance. Transplantation. 2015;99:1817-28 pubmed publisher
flow cytometry; mouse; fig 4 immunocytochemistry; mouse; fig 4	Williams K, Mella H, Lucas P, Williams J, Telford W, Gress R. Single cell analysis of complex thymus stromal cell populations: rapid thymic epithelia preparation characterizes radiation injury. Clin Transl Sci. 2009;2:279-85 pubmed publisher
	Xie C, Gao X, Liu G, Tang H, Li C. USP10 is a potential mediator for vagus nerve stimulation to alleviate neuroinflammation in ischaemic stroke by inhibiting NF-κB signalling pathway. Front Immunol. 2023;14:1130697 pubmed publisher
	Luan D, Dadpey B, Zaid J, Bridge Comer P, DeLuca J, Xia W, et al. Adipocyte-Secreted IL-6 Sensitizes Macrophages to IL-4 Signaling. Diabetes. 2023;72:367-374 pubmed publisher
	Parker E, Khayrullin A, Kent A, Mendhe B, Youssef El Baradie K, Yu K, et al. Hindlimb Immobilization Increases IL-1β and Cdkn2a Expression in Skeletal Muscle Fibro-Adipogenic Progenitor Cells: A Link Between Senescence and Muscle Disuse Atrophy. Front Cell Dev Biol. 2021;9:790437 pubmed publisher
	Hong M, Han I, Choi I, Cha N, Kim W, Kim S, et al. Magnoliae Cortex Alleviates Muscle Wasting by Modulating M2 Macrophages in a Cisplatin-Induced Sarcopenia Mouse Model. Int J Mol Sci. 2021;22: pubmed publisher
	Teng Y, Porfírio Sousa A, Ribeiro G, Arend M, da Silva Meirelles L, Chen E, et al. Analyses of the pericyte transcriptome in ischemic skeletal muscles. Stem Cell Res Ther. 2021;12:183 pubmed publisher
	Singh S, Xiao Z, Bavisi K, Roszik J, Melendez B, Wang Z, et al. IL-1α Mediates Innate and Acquired Resistance to Immunotherapy in Melanoma. J Immunol. 2021;206:1966-1975 pubmed publisher
	Nadafi R, Gago de Graça C, Keuning E, Koning J, de Kivit S, Konijn T, et al. Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses. Cell Rep. 2020;30:4110-4123.e4 pubmed publisher
	Madaro L, Torcinaro A, De Bardi M, Contino F, Pelizzola M, Diaferia G, et al. Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice. PLoS Genet. 2019;15:e1008408 pubmed publisher
	Kolter J, Feuerstein R, Zeis P, Hagemeyer N, Paterson N, d Errico P, et al. A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity. 2019;50:1482-1497.e7 pubmed publisher
	Wen H, Gao S, Wang Y, Ray M, Magnuson M, Wright C, et al. Myeloid cell-derived HB-EGF Drives Tissue Recovery After Pancreatitis. Cell Mol Gastroenterol Hepatol. 2019;: pubmed publisher
	Zhang Z, Hunter L, Wu G, Maidstone R, Mizoro Y, Vonslow R, et al. Genome-wide effect of pulmonary airway epithelial cell-specific Bmal1 deletion. FASEB J. 2019;33:6226-6238 pubmed publisher
	Dammone G, Karaz S, Lukjanenko L, Winkler C, Sizzano F, Jacot G, et al. PPARγ Controls Ectopic Adipogenesis and Cross-Talks with Myogenesis During Skeletal Muscle Regeneration. Int J Mol Sci. 2018;19: pubmed publisher
	Ince L, Zhang Z, Beesley S, Vonslow R, Saer B, Matthews L, et al. Circadian variation in pulmonary inflammatory responses is independent of rhythmic glucocorticoid signaling in airway epithelial cells. FASEB J. 2019;33:126-139 pubmed publisher
	da Silva I, Chammas R, Lepique A, Jancar S. Platelet-activating factor (PAF) receptor as a promising target for cancer cell repopulation after radiotherapy. Oncogenesis. 2017;6:e296 pubmed publisher
	Zaynagetdinov R, Stathopoulos G, Sherrill T, Cheng D, McLoed A, Ausborn J, et al. Epithelial nuclear factor-?B signaling promotes lung carcinogenesis via recruitment of regulatory T lymphocytes. Oncogene. 2012;31:3164-76 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45 Monoclonal Antibody (30-F11), Pacific Blue

Catalog # :

MCD4528

Quantity :

1 mL

Price :

US 413.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay-dependent

Species :

Mouse

Clone :

30-F11

Isotype :

IgG2b, kappa

Storage :

4 C

Description :

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions.

Immunogen :

The CD45 antigen

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

B220; cd45; CD45 antigen; CD45 antigen isoform 1 precursor; CD45 antigen isoform 2 precursor; CD45 antigen isoform 3 precursor; CD45 antigen isoform 4 precursor; CD45 antigen isoform 5 precursor; CD45 antigen isoform 6 precursor; CD45R; GP180; Lca; L-CA; leucocyte common antigen; leukocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; leukocyte common antigen, CD45; loc; LOW QUALITY PROTEIN: receptor-type tyrosine-protein phosphatase C; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; membrane tyrosine phosphatase; protein tyrosine phosphatase lambda; protein tyrosine phosphatase receptor type C; protein tyrosine phosphatase, receptor type C; protein tyrosine phosphatase, receptor type, C; protein tyrosine phosphatase, receptor type, c polypeptide; Protein tyrosine phosphatase, receptor-type, c polypeptide; protein tyrosine phosphatase; alternatively spliced; Ptprc; Receptor-type tyrosine-protein phosphatase C; RT7; T200; T200 glycoprotein; T200 leukocyte common antigen; T220 and B220

more info or order :

Invitrogen product webpage