CD45.2 Monoclonal Antibody (104), FITC | Invitrogen MCD45201 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD45.2 Monoclonal Antibody (104), FITC

catalog :

MCD45201

quantity :

500 ug

price :

US 576.00

clonality :

monoclonal

host :

mouse

conjugate :

FITC

clone name :

104

reactivity :

mouse

application :

flow cytometry, immunohistochemistry - frozen section

more info or order :

Invitrogen product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; loading ...; fig s6a	Hall B, Gleiberman A, Strom E, Krasnov P, Frescas D, Vujcic S, et al. Immune checkpoint protein VSIG4 as a biomarker of aging in murine adipose tissue. Aging Cell. 2020;19:e13219 pubmed publisher
flow cytometry; mouse; 1:500; fig 6g	Gang E, Kim H, Hsieh Y, Ruan Y, Ogana H, Lee S, et al. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020;136:210-223 pubmed publisher
flow cytometry; mouse; 1:300; loading ...; fig 2f, 2g	Zhu L, Xie X, Zhang L, Wang H, Jie Z, Zhou X, et al. TBK-binding protein 1 regulates IL-15-induced autophagy and NKT cell survival. Nat Commun. 2018;9:2812 pubmed publisher
flow cytometry; mouse; 1:200; loading ...; fig s4b	Yeh C, Nojima T, Kuraoka M, Kelsoe G. Germinal center entry not selection of B cells is controlled by peptide-MHCII complex density. Nat Commun. 2018;9:928 pubmed publisher
immunohistochemistry - frozen section; mouse; fig 2b	Herrtwich L, Nanda I, Evangelou K, Nikolova T, Horn V, Sagar -, et al. DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas. Cell. 2016;167:1264-1280.e18 pubmed publisher
flow cytometry; mouse; loading ...	Lindner J, Wong C, Möller A, Nielsen P. A C-terminal acidic domain regulates degradation of the transcriptional coactivator Bob1. Mol Cell Biol. 2013;33:4628-40 pubmed publisher
	Lo W, Kuhlmann M, Rizzuto G, Ekiz H, Kolawole E, Revelo M, et al. A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function. Nat Immunol. 2023;24:676-689 pubmed publisher
	Shereen M, Bashir N, Su R, Liu F, Wu K, Luo Z, et al. Zika virus dysregulates the expression of astrocytic genes involved in neurodevelopment. PLoS Negl Trop Dis. 2021;15:e0009362 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD45.2 Monoclonal Antibody (104), FITC

Catalog # :

MCD45201

Quantity :

500 ug

Price :

US 576.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Mouse

Applications :

Flow Cytometry: 1 ug/1x10^6 cells

Species :

Mouse

Clone :

104

Isotype :

IgG2a, kappa

Storage :

4 C, store in dark

Description :

CD45.2 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45.2 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45.2 protein exists as multiple isoforms as a result of alternative splicing; these isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. Besides the role in immunoreceptor signaling, CD45.2 is important in promoting cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells.

Immunogen :

B10.S mouse thymocytes and splenocytes.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/1x10^6 cells

Aliases :

B220; Cd45; CD45 antigen; CD45R; GP180; LCA; L-CA; leukocyte common antigen; loc; LY5; Ly-5; lymphocyte antigen 5; lymphocyte common antigen; Lyt-4; protein tyrosine phosphatase, receptor type, C; Ptprc; Receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein

more info or order :

Invitrogen product webpage