product summary
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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CD4 Monoclonal Antibody (RM4-5), Pacific Orange
catalog :
MCD0430
quantity :
1 mL
price :
US 506.00
clonality :
monoclonal
host :
rat
conjugate :
pacific orange
clone name :
RM4-5
reactivity :
mouse
application :
flow cytometry, immunohistochemistry - frozen section
more info or order :
Invitrogen product webpage
citations: 20
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; loading ...; fig 1d
Olofsson P, Steinberg B, Sobbi R, Cox M, Ahmed M, Oswald M, et al. Blood pressure regulation by CD4+ lymphocytes expressing choline acetyltransferase. Nat Biotechnol. 2016;34:1066-1071 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Roffê E, Marino A, Weaver J, Wan W, de Araújo F, Hoffman V, et al. Trypanosoma cruzi Causes Paralyzing Systemic Necrotizing Vasculitis Driven by Pathogen-Specific Type I Immunity in Mice. Infect Immun. 2016;84:1123-1136 pubmed publisher
  • flow cytometry; mouse
Nacer A, Movila A, Sohet F, Girgis N, Gundra U, Loke P, et al. Experimental cerebral malaria pathogenesis--hemodynamics at the blood brain barrier. PLoS Pathog. 2014;10:e1004528 pubmed publisher
  • flow cytometry; mouse
Carty S, Koretzky G, Jordan M. Interleukin-4 regulates eomesodermin in CD8+ T cell development and differentiation. PLoS ONE. 2014;9:e106659 pubmed publisher
  • flow cytometry; mouse
Reeh K, Cardenas K, Bain V, Liu Z, LAURENT M, Manley N, et al. Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development. 2014;141:2950-8 pubmed publisher
  • flow cytometry; mouse
Frese Schaper M, Keil A, Yagita H, Steiner S, Falk W, Schmid R, et al. Influence of natural killer cells and perforin?mediated cytolysis on the development of chemically induced lung cancer in A/J mice. Cancer Immunol Immunother. 2014;63:571-80 pubmed
  • flow cytometry; mouse; 1:100
Fu H, Kishore M, Gittens B, Wang G, Coe D, Komarowska I, et al. Self-recognition of the endothelium enables regulatory T-cell trafficking and defines the kinetics of immune regulation. Nat Commun. 2014;5:3436 pubmed publisher
  • flow cytometry; mouse; fig 1
McPhee C, Bubier J, Sproule T, Park G, Steinbuck M, Schott W, et al. IL-21 is a double-edged sword in the systemic lupus erythematosus-like disease of BXSB.Yaa mice. J Immunol. 2013;191:4581-8 pubmed publisher
  • flow cytometry; mouse; fig 2
Fuertbauer E, Zaujec J, Uhrin P, Raab I, Weber M, Schachner H, et al. Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells. Immunol Lett. 2013;154:31-41 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2c
Mathew R, Seiler M, Scanlon S, Mao A, Constantinides M, Bertozzi Villa C, et al. BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs. Nature. 2012;491:618-21 pubmed publisher
  • flow cytometry; mouse; fig 3
McPhee C, Sproule T, Shin D, Bubier J, Schott W, Steinbuck M, et al. MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis. J Immunol. 2011;187:4695-704 pubmed publisher
  • flow cytometry; mouse; fig 2
Maris C, Miller J, Altman J, Jacob J. A transgenic mouse model genetically tags all activated CD8 T cells. J Immunol. 2003;171:2393-401 pubmed
Chen F, Xu Y, Chen Y, Shan S. TIGIT enhances CD4+ regulatory T-cell response and mediates immune suppression in a murine ovarian cancer model. Cancer Med. 2020;9:3584-3591 pubmed publisher
Shastri A, Choudhary G, Teixeira M, Gordon Mitchell S, Ramachandra N, Bernard L, et al. Antisense STAT3 inhibitor decreases viability of myelodysplastic and leukemic stem cells. J Clin Invest. 2018;128:5479-5488 pubmed publisher
Pelly V, Coomes S, Kannan Y, Gialitakis M, Entwistle L, Perez Lloret J, et al. Interleukin 4 promotes the development of ex-Foxp3 Th2 cells during immunity to intestinal helminths. J Exp Med. 2017;214:1809-1826 pubmed publisher
Geiger R, Rieckmann J, Wolf T, Basso C, Feng Y, Fuhrer T, et al. L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity. Cell. 2016;167:829-842.e13 pubmed publisher
Pugh J, Foster S, Sukhina A, Petravic J, Uhrlaub J, Padilla Torres J, et al. Acute systemic DNA damage in youth does not impair immune defense with aging. Aging Cell. 2016;15:686-93 pubmed publisher
Pelly V, Kannan Y, Coomes S, Entwistle L, Rückerl D, Seddon B, et al. IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection. Mucosal Immunol. 2016;9:1407-1417 pubmed publisher
Bökers S, Urbat A, Daniel C, Amann K, Smith K, Espéli M, et al. Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice. J Immunol. 2014;192:2994-3002 pubmed publisher
Woolard M, Hensley L, Kawula T, Frelinger J. Respiratory Francisella tularensis live vaccine strain infection induces Th17 cells and prostaglandin E2, which inhibits generation of gamma interferon-positive T cells. Infect Immun. 2008;76:2651-9 pubmed publisher
product information
Product Type :
Antibody
Product Name :
CD4 Monoclonal Antibody (RM4-5), Pacific Orange
Catalog # :
MCD0430
Quantity :
1 mL
Price :
US 506.00
Clonality :
Monoclonal
Purity :
purified
Host :
Rat
Reactivity :
Mouse
Applications :
Flow Cytometry: Assay-dependent
Species :
Mouse
Clone :
RM4-5
Isotype :
IgG2a
Storage :
4 C
Description :
The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].
Immunogen :
Mouse CD4
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: Assay-dependent
Aliases :
Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA