CD4 Monoclonal Antibody (RM4-5), Alexa Fluor 488 | Invitrogen MCD0420 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD4 Monoclonal Antibody (RM4-5), Alexa Fluor 488

catalog :

MCD0420

quantity :

1 mL

price :

282 USD

clonality :

monoclonal

host :

rat

conjugate :

AF488

clone name :

RM4-5

reactivity :

mouse

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 7

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; fig 1	Wang J, New J, Xie S, Yang P, Wu Q, Li J, et al. Extension of the germinal center stage of B cell development promotes autoantibodies in BXD2 mice. Arthritis Rheum. 2013;65:2703-12 pubmed publisher
immunohistochemistry; mouse	Albornoz E, Carreño L, Cortes C, González P, Cisternas P, Cautivo K, et al. Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring. Thyroid. 2013;23:1627-37 pubmed publisher
immunocytochemistry; mouse; fig s3	Weisel F, Appelt U, Schneider A, Horlitz J, Van Rooijen N, Korner H, et al. Unique requirements for reactivation of virus-specific memory B lymphocytes. J Immunol. 2010;185:4011-21 pubmed publisher
immunohistochemistry; mouse; fig 2a	Wang J, Li J, Wu Q, Yang P, Pawar R, Xie S, et al. Marginal zone precursor B cells as cellular agents for type I IFN-promoted antigen transport in autoimmunity. J Immunol. 2010;184:442-51 pubmed publisher
	Hayashi Y, Call M, Chikama T, Liu H, Carlson E, Sun Y, et al. Lumican is required for neutrophil extravasation following corneal injury and wound healing. J Cell Sci. 2010;123:2987-95 pubmed publisher
	Gebe J, Unrath K, Yue B, Miyake T, Falk B, Nepom G. Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice. J Autoimmun. 2008;30:197-206 pubmed
	Gebe J, Unrath K, Falk B, Ito K, Wen L, Daniels T, et al. Age-dependent loss of tolerance to an immunodominant epitope of glutamic acid decarboxylase in diabetic-prone RIP-B7/DR4 mice. Clin Immunol. 2006;121:294-304 pubmed

product information

Product Type :

Antibody

Product Name :

CD4 Monoclonal Antibody (RM4-5), Alexa Fluor 488

Catalog # :

MCD0420

Quantity :

1 mL

Price :

282 USD

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay Dependent

Species :

Mouse

Clone :

RM4-5

Isotype :

IgG2a

Storage :

4° C

Description :

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

Immunogen :

Mouse CD4

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay Dependent

Aliases :

CD4 antigen p55, CD4 receptor, T-cell surface antigen T4/Leu-3, T-cell surface glycoprotein CD4