CD4 Monoclonal Antibody (RM4-5), PE-Texas Red | Invitrogen MCD0417 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD4 Monoclonal Antibody (RM4-5), PE-Texas Red

catalog :

MCD0417

quantity :

500 uL

price :

US 438.00

clonality :

monoclonal

host :

rat

conjugate :

PE Texas Red

clone name :

RM4-5

reactivity :

mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 14

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:100; loading ...; fig 3, 5	Aslan K, Turco V, Blobner J, Sonner J, Liuzzi A, Núñez N, et al. Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas. Nat Commun. 2020;11:931 pubmed publisher
flow cytometry; mouse; fig 1	Chuprin A, Avin A, Goldfarb Y, Herzig Y, Levi B, Jacob A, et al. The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance. Nat Immunol. 2015;16:737-45 pubmed publisher
flow cytometry; mouse	Saligrama N, Case L, Krementsov D, Teuscher C. Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J. 2014;28:1898-909 pubmed publisher
flow cytometry; mouse; fig 5	Krementsov D, Wall E, Martin R, Subramanian M, Noubade R, del Rio R, et al. Histamine H(3) receptor integrates peripheral inflammatory signals in the neurogenic control of immune responses and autoimmune disease susceptibility. PLoS ONE. 2013;8:e62743 pubmed publisher
flow cytometry; mouse; fig S1	Saligrama N, Case L, del Rio R, Noubade R, Teuscher C. Systemic lack of canonical histamine receptor signaling results in increased resistance to autoimmune encephalomyelitis. J Immunol. 2013;191:614-22 pubmed publisher
flow cytometry; mouse; fig 1	Cravens P, Kieseier B, Hussain R, Herndon E, Arellano B, Ben L, et al. The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis. J Neuroinflammation. 2013;10:67 pubmed publisher
flow cytometry; mouse; fig 4	Saligrama N, Noubade R, Case L, del Rio R, Teuscher C. Combinatorial roles for histamine H1-H2 and H3-H4 receptors in autoimmune inflammatory disease of the central nervous system. Eur J Immunol. 2012;42:1536-46 pubmed publisher
flow cytometry; mouse; fig 5	Blankenhorn E, Butterfield R, Case L, Wall E, del Rio R, DIEHL S, et al. Genetics of experimental allergic encephalomyelitis supports the role of T helper cells in multiple sclerosis pathogenesis. Ann Neurol. 2011;70:887-96 pubmed publisher
flow cytometry; mouse; fig 4	del Rio R, Noubade R, Saligrama N, Wall E, Krementsov D, Poynter M, et al. Histamine H4 receptor optimizes T regulatory cell frequency and facilitates anti-inflammatory responses within the central nervous system. J Immunol. 2012;188:541-7 pubmed publisher
flow cytometry; mouse; fig 1	Chen B, Cui X, Sempowski G, Domen J, Chao N. Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. Blood. 2004;103:4344-52 pubmed
	Park J, Gazzaniga F, Wu M, Luthens A, Gillis J, Zheng W, et al. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023;617:377-385 pubmed publisher
	Casadesús A, Deligne C, Diallo B, Sosa K, Josseaume N, Mesa C, et al. A rationally-engineered IL-2 improves the antitumor effect of anti-CD20 therapy. Oncoimmunology. 2020;9:1770565 pubmed publisher
	Sagnella S, Yang L, Stubbs G, Boslem E, Martino Echarri E, Smolarczyk K, et al. Cyto-Immuno-Therapy for Cancer: A Pathway Elicited by Tumor-Targeted, Cytotoxic Drug-Packaged Bacterially Derived Nanocells. Cancer Cell. 2020;37:354-370.e7 pubmed publisher
	Tse M, Lane C, Mott K, Onlamoon N, Hsiao H, Perng G. ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection. J Neuroimmunol. 2009;213:12-9 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD4 Monoclonal Antibody (RM4-5), PE-Texas Red

Catalog # :

MCD0417

Quantity :

500 uL

Price :

US 438.00

Clonality :

Monoclonal

Purity :

purified

Host :

Rat

Reactivity :

Mouse

Applications :

Flow Cytometry: Assay-dependent

Species :

Mouse

Clone :

RM4-5

Isotype :

IgG2a

Storage :

4 C

Description :

The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017].

Immunogen :

Mouse CD4

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-dependent

Aliases :

Activation B7-1 antigen; B7; B7.1; B7-1; BB1; B-lymphocyte activation antigen B7; CD28LG; CD28LG1; CD4; CD4 antigen; CD4 antigen (p55); CD4 antigen p55; Cd4 molecule; CD4 precursor; CD4 receptor; CD4, allele 1; cd4a; CD4mut; CD80; CD80 antigen (CD28 antigen ligand 1, B7-1 antigen); CD80 molecule; cell surface glycoprotein CD4; costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; fCD4; L3T4; LAB7; Leu-3; Ly-4; lymphocyte antigen CD4; lymphocyte antigen CD4 precursor; membrane protein; p55; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4; T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4/Leu-3) (T-cell differentiation antigen L3T4); T-lymphocyte activation antigen CD80; W3/25; W3/25 antigen

more info or order :

Invitrogen product webpage