TNF alpha Monoclonal Antibody (E10011) | Invitrogen MBOTNFAI product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TNF alpha Monoclonal Antibody (E10011)

catalog :

MBOTNFAI

quantity :

500µg

price :

329 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

E10011

reactivity :

cow

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

TNF alpha Monoclonal Antibody (E10011)

Catalog # :

MBOTNFAI

Quantity :

500µg

Price :

329 USD

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Bovine

Applications :

ELISA: Assay Dependent, Western Blot: Assay Dependent

Species :

Bovine

Clone :

E10011

Isotype :

IgG1

Storage :

4° C

Description :

TNF alpha is a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophage and bind to its receptors, TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF alpha is involved in the regulation of immune cells, cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. TNF alpha exists as a multimer of two, three, or five noncovalently linked units, but shows a single 17 kDa band following SDS-PAGE under non-reducing conditions. Knockout studies in mice also suggested the neuroprotective function of TNF alpha, and has been observed to causes tumor necrosis when injected into tumor-bearing mice. Other functions of TNF-alpha include its role in the immune response to bacterial, viral, parasitic and certain fungal infections, as well as its role in the necrosis of specific tumors. TNF alpha causes cytolysis or cytostasis of certain transformed cells, being synergistic with interferon-gamma in its cytotoxicity. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer.

Immunogen :

Recombinant bovine TNF alpha purified from Pichia pastoris

Format :

Lyophilized

Applications w/Dilutions :

ELISA: Assay Dependent, Western Blot: Assay Dependent

Aliases :

TNF-a; TNF-alpha; cachectin; tumor necrosis factor (TNF superfamily, member 2); tumor necrosis factor alpha; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor, alpha (TNF superfamily, member 2)