This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Elezanumab Recombinant Monoclonal Antibody
catalog :
MA5-58393
quantity :
100 ug
price :
US 459.00
clonality :
recombinant
conjugate :
nonconjugated
application :
flow cytometry
product information
Product Type :
Antibody
Product Name :
Elezanumab Recombinant Monoclonal Antibody
Catalog # :
MA5-58393
Quantity :
100 ug
Price :
US 459.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Reactivity :
Human
Applications :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Functional Assay: Assay-dependent, Surface plasmon resonance: Assay-dependent
Species :
Human
Isotype :
IgG1
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
Elezanumab is a biosimilar that targets RGMA. Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Format :
Lyophilized
Applications w/Dilutions :
ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Functional Assay: Assay-dependent, Surface plasmon resonance: Assay-dependent
Aliases :
ABT-555; AE12-1Y-QL
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA