This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
SOCS1 Recombinant Rabbit Monoclonal Antibody (6C6W1)
catalog :
MA5-58005
quantity :
20 uL
price :
US 169.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
6C6W1
reactivity :
human, mouse, rat
application :
immunohistochemistry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
SOCS1 Recombinant Rabbit Monoclonal Antibody (6C6W1)
Catalog # :
MA5-58005
Quantity :
20 uL
Price :
US 169.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
ELISA: 1 ug/mL, Immunohistochemistry (Paraffin): 1:100-1:1,000
Species :
Human, Mouse, Rat
Clone :
6C6W1
Isotype :
IgG
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
Immunogen :
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SOCS1 (NP_003736.1).
Format :
Liquid
Applications w/Dilutions :
ELISA: 1 ug/mL, Immunohistochemistry (Paraffin): 1:100-1:1,000
Aliases :
CIS1; Cish1; Cish7; cytokine inducible SH2-containing protein 1; cytokine inducible SH2-containing protein 7; cytokine-inducible SH2 protein 1; JAB; JAK binding protein; JAK2-binding protein; JAK-binding protein; Socs1; SOCS-1; SSI1; SSI-1; STAT induced SH3 protein 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Tec-interacting protein 3; TIP3; TIP-3
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA