B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (4R4T5) | Invitrogen MA5-57888 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (4R4T5)

catalog :

MA5-57888

quantity :

100 uL

price :

US 419.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

4R4T5

reactivity :

human

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

B-Raf (V600E) Recombinant Rabbit Monoclonal Antibody (4R4T5)

Catalog # :

MA5-57888

Quantity :

100 uL

Price :

US 419.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Western Blot: 1:500-1:1,000

Species :

Human

Clone :

4R4T5

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

This gene, B-RAF/BRAF, encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERK signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene, most commonly the V600E mutation, are the most frequently identified cancer-causing mutations in melanoma, and have been identified in various other cancers as well, including non-Hodgkin lymphoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia and adenocarcinoma of lung. Mutations in this gene are also associated with cardiofaciocutaneous, Noonan, and Costello syndromes, which exhibit overlapping phenotypes. A pseudogene of this gene has been identified on the X chromosome.

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 507-606 of B-Raf (NP_004324.2).

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Western Blot: 1:500-1:1,000