This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
MBD1 Recombinant Rabbit Monoclonal Antibody (24GB405)
catalog :
MA5-57471
quantity :
20 uL
price :
US 189.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
24GB405
reactivity :
human, rat
application :
western blot, flow cytometry
product information
Product Type :
Antibody
Product Name :
MBD1 Recombinant Rabbit Monoclonal Antibody (24GB405)
Catalog # :
MA5-57471
Quantity :
20 uL
Price :
US 189.00
Clonality :
Recombinant Monoclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human, Rat
Applications :
Flow Cytometry: 1:2,000, Western Blot: 1:1,000-1:5,000
Species :
Human, Rat
Clone :
24GB405
Isotype :
IgG
Storage :
-20 C
Description :
Methyl-CpG-binding domain protein 1 (MBD1) is a member of a family of mammalian proteins that specifically bind methylated regions of DNA. It is a transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). MBD1 acts as a transcriptional repressor and plays a role in gene silencing by recruiting AFT7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Immunogen :
A synthesized peptide derived from human MBD1 (aa 550-605)
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:2,000, Western Blot: 1:1,000-1:5,000
Aliases :
CXXC3; CXXC-type zinc finger protein 3; Mbd1; methyl-CpG binding domain protein 1; methyl-CpG binding domain protein 1 isoform PCM1; methyl-CpG-binding domain protein 1; Methyl-CpG-binding protein MBD1; PCM1; Protein containing methyl-CpG-binding domain 1; RFT; the regulator of fibroblast growth factor 2 (FGF-2) transcription
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA