MADD Recombinant Rabbit Monoclonal Antibody (24GB110) | Invitrogen MA5-57457 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MADD Recombinant Rabbit Monoclonal Antibody (24GB110)

catalog :

MA5-57457

quantity :

20 uL

price :

US 189.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

24GB110

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

product information

Product Type :

Antibody

Product Name :

MADD Recombinant Rabbit Monoclonal Antibody (24GB110)

Catalog # :

MA5-57457

Quantity :

20 uL

Price :

US 189.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:2,000, Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse, Rat

Clone :

24GB110

Isotype :

IgG

Storage :

-20 C

Description :

Tumor necrosis factor receptor 1 (TNFR1) contains a death receptor domain that mediates interactions involved in downstream signaling of TNF. A novel protein, MADD (mitogen activated protein (MAP)-kinase activating death domain protein) has recently been shown to associate with the death domain of TNFR1 through its own C-terminal death domain. This interaction is critical for TNFR1 signal generation. Overexpression of MADD activates the MAP (Mitogen Activated Protein) kinases extracellular signal-related kinase (ERK) and c-Jun N-terminal kinase (JNK) and induces the phosphorylation of cytosolic phospholipase A2. This discovery suggests that MADD links tumor necrosis factor TNF and MAP kinase activation and arachidonic acid release. MADD has a 98% homology with another protein, differentially expressed in neoplasmic vs. normal cells (DENN). DENN is a substrate for JNK3, and is important in the hypoxia and stress induced intracellular signalling pathways. MADD also has a 93% sequence conservation with a GDP/GTP exchange protein, Rab3.

Immunogen :

A synthesized peptide derived from human DENN (aa 1611-1647)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:2,000, Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:1,000-1:5,000

Aliases :

9630059K23Rik; DENN; differentially expressed in normal and neoplastic cells; IG20; Insulinoma glucagonoma clone 20; insulinoma-glucagonoma protein 20; Kiaa0358; Madd; MAP kinase activating death domain; MAP kinase-activating death domain protein; MAP-kinase activating death domain; rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; Rab3 GEP; RAB3GEP