This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
VAV1/2/3 Recombinant Rabbit Monoclonal Antibody (24GB2645)
catalog :
MA5-57313
quantity :
100 uL
price :
US 479.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
24GB2645
reactivity :
human
application :
western blot, immunocytochemistry
product information
Product Type :
Antibody
Product Name :
VAV1/2/3 Recombinant Rabbit Monoclonal Antibody (24GB2645)
Catalog # :
MA5-57313
Quantity :
100 uL
Price :
US 479.00
Clonality :
Recombinant Monoclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:1,000-1:5,000
Species :
Human
Clone :
24GB2645
Isotype :
IgG
Storage :
-20 C
Description :
The VAV gene family consists of three members: VAV1, VAV2, and VAV3, which are guanine nucleotide exchange factors (GEFs) primarily involved in signal transduction. VAV1, located on chromosome 19p13.2, is predominant in hematopoietic cells and plays a crucial role in T and B lymphocyte signaling, impacting immune responses and cell cycle control. This gene has been implicated in autoimmune diseases as well as several cancers. VAV2, found on chromosome 9q34.1, is ubiquitously expressed and is involved in various cellular processes, such as DNA repair mechanisms and vascular smooth muscle function, with significant implications in cancer where overexpression correlates with tumor progression. VAV3, located on chromosome 1p13.3, shares similar GEF roles and is actively involved in oncogenic processes by mediating Rho GTPase signaling, affecting cell proliferation, migration, and invasion, and is considered a target for cancer therapy. The structural conservation and functional diversity of these proteins underscore their importance in both normal cellular function and disease.
Immunogen :
A synthesized peptide derived from human Vav1/2/3 (aa 750-800)
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:1,000-1:5,000
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA