TUBA1B/TUBA4A Recombinant Rabbit Monoclonal Antibody (24GB2020) | Invitrogen MA5-57300 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TUBA1B/TUBA4A Recombinant Rabbit Monoclonal Antibody (24GB2020)

catalog :

MA5-57300

quantity :

20 uL

price :

US 139.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

24GB2020

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

product information

Product Type :

Antibody

Product Name :

TUBA1B/TUBA4A Recombinant Rabbit Monoclonal Antibody (24GB2020)

Catalog # :

MA5-57300

Quantity :

20 uL

Price :

US 139.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:2,000, Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse, Rat

Clone :

24GB2020

Isotype :

IgG

Storage :

-20 C

Description :

TUBA1B and TUBA4A are genes that encode for alpha-tubulin isoforms, essential components of the microtubule system that plays a critical role in maintaining cell structure, intracellular transport, and cell division. TUBA1B, also known as tubulin alpha-1b chain, is located on chromosome 12q13.12 and has been linked to various cancers due to its influence on microtubule dynamics and cellular proliferation. It is also associated with immune cell infiltration and modulation of immune checkpoints, making it significant in tumor growth and metastasis. TUBA4A, known as tubulin alpha-4A, is found on chromosome 2q35 and is linked to neurodevelopmental disorders and neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mutations in TUBA4A can lead to defects in microtubule stability and function, emphasizing its role in neuronal health. Both genes highlight the critical role of microtubules in cellular and neurological functions, and their mutations can contribute to diverse pathological conditions, including cancer and neurodegenerative diseases.

Immunogen :

A synthesized peptide derived from human TUBA1B/4A (aa 33-47)

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:2,000, Immunocytochemistry: 1:100-1:1,000, Western Blot: 1:1,000-1:5,000