K-Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL2640)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

K-Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL2640)

catalog :

MA5-56855

quantity :

100 uL

price :

US 479.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HL2640

reactivity :

human

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

K-Ras (G12D Mutant) Recombinant Rabbit Monoclonal Antibody (HL2640)

Catalog # :

MA5-56855

Quantity :

100 uL

Price :

US 479.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunocytochemistry: Assay-dependent, Western Blot: 1:500-1:3,000

Species :

Human

Clone :

HL2640

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The K-Ras gene, specifically the G12D mutation, is a well-known oncogene implicated in various types of cancer, including pancreatic, colorectal, and lung cancers. The G12D mutation involves a substitution of glycine (G) with aspartic acid (D) at the 12th position of the K-Ras protein. This mutation leads to a constitutively active K-Ras protein that continuously signals for cell growth and division, bypassing normal regulatory mechanisms. As a result, cells harboring this mutation proliferate uncontrollably, contributing to tumorigenesis. The K-Ras (G12D) mutant is a critical target for cancer research and drug development, as targeting this mutation could potentially inhibit the aberrant signaling pathways and slow down or stop cancer progression. Despite the challenges in targeting mutant K-Ras proteins due to their high affinity for GTP/GDP and lack of suitable binding pockets, ongoing research is focused on developing specific inhibitors and novel therapeutic strategies to effectively target this mutation.

Immunogen :

Synthetic peptide of human RAS (G12D Mutant)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Western Blot: 1:500-1:3,000

Aliases :

K RAS; KRAS; K-Ras