Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Recombinant Rabbit Monoclonal Antibody (JE57-42)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Recombinant Rabbit Monoclonal Antibody (JE57-42)

catalog :

MA5-56570

quantity :

100 uL

price :

US 479.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

JE57-42

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Recombinant Rabbit Monoclonal Antibody (JE57-42)

Catalog # :

MA5-56570

Quantity :

100 uL

Price :

US 479.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Western Blot: 1:1,000

Species :

Human

Clone :

JE57-42

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

PAK4 is highly expressed in prostate, testis and colon. PAK4 interacts tightly with GTP-bound but not GDP-bound CDC42 and weakly with RAC. PAK4 phosphorylates and autophosphorylates and also activates the JNK pathway. PAK5, a member of the PAK family of protein kinases contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. PAK5 preferentially binds to CDC42 in the presence of GTP and the CRIB motif is essential for this interaction. PAK6 protein cotranslocates into the nucleus with androgen receptor, which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development, in response to androgen. PAK6 was initially identified as an androgen receptor in a yeast two hybrid screen and was found to be highly expressed in testis and prostate tissues. Later experiments have shown it to be activated by MAP kinase 6 and p38 MAP kinase, suggesting that PAK6 may play a role in the cellular response to stress-related signals.

Immunogen :

Synthetic phosphopeptide corresponding to residues surrounding Ser474 of human PAK4.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

2900083L08Rik; 4732456M09; 5730488L07Rik; 6430627N20; AW555722; KIAA1142; KIAA1264; mKIAA1142; p21 (CDKN1A)-activated kinase 4; p21 (CDKN1A)-activated kinase 6; p21 (CDKN1A)-activated kinase 7; p21 (RAC1) activated kinase 4; p21 (RAC1) activated kinase 5; p21 (RAC1) activated kinase 6; p21 (RAC1) activated kinase 7; p21 protein (Cdc42/Rac)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 6; p21 protein (Cdc42/Rac)-activated kinase 7; p21(CDKN1A)-activated kinase 4; p21(CDKN1A)-activated kinase 6; p21(CDKN1A)-activated kinase 7; p21-activated kinase 4; p21-activated kinase 5; p21-activated kinase 6; p21-activated kinase 7; p21CDKN1A-activated kinase 7; PAK 4/5/6; PAK 4/6/7; PAK4; PAK-4; PAK4/5/6; PAK5; PAK-5; PAK6; PAK-6; Pak7; PAK-7; protein kinase PAK5; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4; Serine/threonine-protein kinase PAK 5; serine/threonine-protein kinase PAK 6; serine/threonine-protein kinase PAK 6-like; serine/threonine-protein kinase PAK 7; serine/threonine-protein kinase PAK7