Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)

catalog :

MA5-56516

quantity :

100 uL

price :

US 479.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

JE56-35

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Caspase 1 p10/p12 Recombinant Rabbit Monoclonal Antibody (JE56-35)

Catalog # :

MA5-56516

Quantity :

100 uL

Price :

US 479.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:500-1:2,000, Western Blot: 1:2,000

Species :

Human, Mouse, Rat

Clone :

JE56-35

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Caspase-1, also known as Interleukin-1ß-converting enzyme (ICE), is an inflammatory caspase responsible for processing pro-inflammatory cytokines like IL-1 beta and IL-18, and inducing pyroptosis, a form of programmed cell death. The active form of caspase-1 is a heterotetramer consisting of two p20 and two p10 subunits. The p10 subunit arises from the cleavage of the pro-caspase-1 precursor, which is essential for the enzyme's activation and function. The p12 subunit is a fragment derived from the cleavage of the proenzyme, which is involved in enzyme regulation. Upon activation, caspase-1 cleaves its substrates, leading to the initiation of inflammatory responses and pyroptotic pathways. The regulation of these subunits and their precise activities are crucial for maintaining immune homeostasis and responding to infections and tissue damage.

Immunogen :

Recombinant protein within human caspase-1 aa 255-404/404.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:500-1:2,000, Western Blot: 1:2,000