This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
CSNK1A1/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)
catalog :
MA5-56415
quantity :
100 uL
price :
US 479.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
PSH04-58

The same clone is also sold as:
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
product information
Product Type :
Antibody
Product Name :
CSNK1A1/CSNK1A1L Recombinant Rabbit Monoclonal Antibody (PSH04-58)
Catalog # :
MA5-56415
Quantity :
100 uL
Price :
US 479.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human, Mouse, Rat
Applications :
Flow Cytometry: 1:1,000, Immunocytochemistry: 1:500, Immunohistochemistry (Paraffin): 1:1,000, Immunoprecipitation: 1-2 ug, Western Blot: 1:2,000
Species :
Human, Mouse, Rat
Clone :
PSH04-58
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
CSNK1A1 (casein kinase 1 alpha 1) and CSNK1A1L (casein kinase 1 alpha 1-like) are serine/threonine protein kinases involved in various cellular processes. CSNK1A1 is located on chromosome 5 (5q32) and functions as a putative tumor suppressor, playing a role in cell cycle regulation, apoptosis, and autophagy. It is involved in the CGAS-STING pathway, inhibiting the overactivation of type I interferon signaling by promoting autophagic degradation of STING1. Additionally, CSNK1A1 has implications in certain cancers and myelodysplastic syndromes where its regulation affects cell proliferation and sensitivity to therapies. In contrast, CSNK1A1L is a paralog of CSNK1A1 that shares similar functional domains and potentially overlapping functions, although its specific role and regulatory mechanisms remain less characterized. Both genes are involved in critical pathways regulating cell survival and immune response, and their dysregulation is associated with disease states.
Immunogen :
Recombinant protein within human CSNK1A1 aa 1-337/337.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:1,000, Immunocytochemistry: 1:500, Immunohistochemistry (Paraffin): 1:1,000, Immunoprecipitation: 1-2 ug, Western Blot: 1:2,000
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA