BRCC3 Recombinant Rabbit Monoclonal Antibody (PSH05-10) | Invitrogen MA5-56411 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

BRCC3 Recombinant Rabbit Monoclonal Antibody (PSH05-10)

catalog :

MA5-56411

quantity :

100 uL

price :

US 479.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

PSH05-10

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

BRCC3 Recombinant Rabbit Monoclonal Antibody (PSH05-10)

Catalog # :

MA5-56411

Quantity :

100 uL

Price :

US 479.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:1,000, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:2,000, Western Blot: 1:2,000

Species :

Human, Mouse, Rat

Clone :

PSH05-10

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Together with the breast and ovarian predisposition proteins BRCA1 and BRCA2 and RAD51 and BRCC45, BRCC36 forms a holoenzyme complex that possesses a ubiquitin E3 ligase activity. Aberrant levels of BRCC36 were detected in sporadic breast tumors and depletion of either BRCC36 or BRCC45 by siRNA resulted in increased sensitivity to ionizing radiation and defects in the G2/M checkpoint, indicating that BRCC36 acts to enhance cellular survival following DNA damage. Recent experiments have shown that BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation, suggesting that BRCC36 may be an important target in the treatment of radiation-resistant breast tumors. At least two isoforms of BRCC36 are known to exist.

Immunogen :

Recombinant protein within human BRCC36 aa 1-316/316.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:1,000, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:2,000, Western Blot: 1:2,000

Aliases :

6.1A protein; BRCA1/BRCA2-containing complex subunit 3; BRCA1/BRCA2-containing complex subunit 36; BRCA1/BRCA2-containing complex, subunit 3; BRCA1-A complex subunit BRCC36; Brcc3; BRCC36; BRISC complex subunit BRCC36; C6.1A; CXorf53; lys-63-specific deubiquitinase BRCC36; RP11-143H17.2