CHCHD6 Monoclonal Antibody (K56003_20B7) | Invitrogen MA5-56071 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CHCHD6 Monoclonal Antibody (K56003_20B7)

catalog :

MA5-56071

quantity :

200 ug

price :

US 809.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

K56003_20B7

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

CHCHD6 Monoclonal Antibody (K56003_20B7)

Catalog # :

MA5-56071

Quantity :

200 ug

Price :

US 809.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000

Species :

Human, Mouse

Clone :

K56003_20B7

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CHCHD6 is a member of a family of proteins containing a conserved (coiled coil 1)-(helix 1)-(coiled coil 2)-(helix 2) domain and has been observed in a complex with the mitochondrial proteins mitofilin, SAM50, metaxins 1 and 2, and CHCHD3. CHCHD6 knockdown causes severe defects in mitochondrial cristae morphology as well as reductions in cell growth, ATP production and oxygen consumption. This decrease of CHCHD6 also led to a reduction in mitofilin protein levels, while a knockdown of mitofilin resulted in a reduced level of CHCHD6, suggesting coordinate regulation between these two proteins. CHCHD6 knockdown in human cancer cells enhances their sensitivity to genotoxic anticancer drugs, suggesting that CHCHD6 may be a potential therapeutic anti-tumor target.

Immunogen :

Recombinant human CHCHD6 (immunogen range is 11-190).

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000

Aliases :

0710001P09Rik; 1700021B03Rik; CHCHD6; CHCM1; coiled coil helix cristae morphology 1; coiled coil helix cristae morphology protein 1; coiled-coil-helix cristae morphology 1; coiled-coil-helix cristae morphology protein 1; coiled-coil-helix-coiled-coil-helix domain containing 6; Coiled-coil-helix-coiled-coil-helix domain-containing protein 6; coiled-coil-helix-coiled-coil-helix domain-containing protein 6, mitochondrial; Mic25; MICOS complex subunit MIC25; PPP1R23; protein phosphatase 1, regulatory subunit 23