PSME1 Monoclonal Antibody (KAA124_8B6) | Invitrogen MA5-55975 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSME1 Monoclonal Antibody (KAA124_8B6)

catalog :

MA5-55975

quantity :

50 ug

price :

US 499.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

KAA124_8B6

reactivity :

human

application :

western blot, ELISA, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

PSME1 Monoclonal Antibody (KAA124_8B6)

Catalog # :

MA5-55975

Quantity :

50 ug

Price :

US 499.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: 1-3 ug/mL, Immunoprecipitation: 10 ug/mL, Western Blot: 1 ug/mL

Species :

Human

Clone :

KAA124_8B6

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Immunogen :

Recombinant human PSME1 (immunogen range is 1-249).

Format :

Liquid

Applications w/Dilutions :

ELISA: 1-3 ug/mL, Immunoprecipitation: 10 ug/mL, Western Blot: 1 ug/mL

Aliases :

11S regulator complex subunit alpha; 29-kD MCP activator subunit; activator of multicatalytic protease subunit 1; AW413925; epididymis secretory sperm binding protein Li 129m; HEL-S-129m; I79_008549; IFI5111; IGUP I-5111; interferon gamma up-regulated I-5111 protein; interferon-gamma IEF SSP 5111; interferon-gamma-inducible protein 5111; MGC8628; OTTHUMP00000164702; PA28 alpha subunit; PA28a; PA28alpha; protease (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) 28 subunit, alpha; proteasome (prosome, macropain) activator subunit 1; proteasome (prosome, macropain) activator subunit 1 (PA28 alpha); proteasome activator 28 subunit alpha; Proteasome activator complex subunit 1; proteasome activator subunit 1; Psme1; REGalpha; REG-alpha