Securin Monoclonal Antibody (K49008_2B9) | Invitrogen MA5-55775 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Securin Monoclonal Antibody (K49008_2B9)

catalog :

MA5-55775

quantity :

50 ug

price :

US 419.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

K49008_2B9

reactivity :

human

application :

western blot

product information

Product Type :

Antibody

Product Name :

Securin Monoclonal Antibody (K49008_2B9)

Catalog # :

MA5-55775

Quantity :

50 ug

Price :

US 419.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Western Blot: 1:1,000

Species :

Human

Clone :

K49008_2B9

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Immunogen :

Recombinant human PTTG1 (immunogen range is 1-202).

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

AW555095; C87862; EAP1; Esp1-associated protein; ESP1-associated protein 1; HPTTG; MGC126883; MGC138276; Pituitary tumor transforming; pituitary tumor-transforming 1; pituitary tumor-transforming gene 1; pituitary tumor-transforming gene 1 protein; PTTG; PTTG1; Pttg3; Securin; tumor-transforming protein 1; TUTR1