FPGS Recombinant Rabbit Monoclonal Antibody (7E2H1) | Invitrogen MA5-55448 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FPGS Recombinant Rabbit Monoclonal Antibody (7E2H1)

catalog :

MA5-55448

quantity :

100 uL

price :

US 419.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

7E2H1

reactivity :

human, rat

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

FPGS Recombinant Rabbit Monoclonal Antibody (7E2H1)

Catalog # :

MA5-55448

Quantity :

100 uL

Price :

US 419.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

ELISA: 1 ug/mL, Western Blot: 1:100-1:500

Species :

Human, Rat

Clone :

7E2H1

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. Folylpoly-gamma-glutamate synthetase has three functions in folate homeostasis in mammals: polyglutamation prevents efflux of folate cofactors from the cell, it increases the binding of folate cofactors to some of the enzymes of folate interconversion and biosynthesis, and it appears to allow the accumulation of folates in the mitochondria that are required for glycine synthesis. Folylpoly-gamma-glutamate synthetase is widely expressed in human tumors and is tightly linked either to proliferation or to a lack of differentiation. The cytotoxicity of both thymidylate synthase and purine inhibitors requires continued inhibition of target for greater than one generation time, so that the integrative function of FPGS adds considerably to the efficiency of folate antimetabolites.

Immunogen :

Recombinant fusion protein containing a sequence corresponding to amino acids 450-587 of human FPGS.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:100-1:500

Aliases :

AA408187; folylpoly-gamma-glutamate synthetase; folylpolyglutamate synthase; folylpolyglutamate synthase, mitochondrial; folylpolyglutamyl synthetase; FPGS; Tetrahydrofolate synthase; tetrahydrofolylpolyglutamate synthase