pro MMP9 Recombinant Rabbit Monoclonal Antibody (2N4X3) | Invitrogen MA5-55331 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

pro MMP9 Recombinant Rabbit Monoclonal Antibody (2N4X3)

catalog :

MA5-55331

quantity :

100 uL

price :

US 419.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

2N4X3

reactivity :

mouse

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

pro MMP9 Recombinant Rabbit Monoclonal Antibody (2N4X3)

Catalog # :

MA5-55331

Quantity :

100 uL

Price :

US 419.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Mouse

Applications :

ELISA: 1 ug/mL, Western Blot: 1:1,000-1:10,000

Species :

Mouse

Clone :

2N4X3

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

MMP9 (matrix metallopeptidase 9, GELB, CLG4B) is a matrix metalloproteinase, a family of zinc and calcium-dependent endopeptidases that degrade extracellular matrix proteins. MMP9 is secreted as a 92kDa zymogen and cleavage of pro-MMP9 results in the active enzyme with a molecular weight of 82kDa. MMP9 has a gelatin-binding domain consisting of three fibronectin type II units, a catalytic domain containing the zinc-binding site, a proline-rich type V collagen-homologous domain and a hemopexin-like domain. MMP9 is produced by monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts and endothelial cells, and is involved in inflammatory responses, tissue remodeling, wound healing, tumor growth and metastasis. MMP9 is supplied by bone marrow-derived cells and contributes to skin carcinogenesis. Further, MMP9 degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. Studies have shown that elevated MMP9 is associated with progression of idiopathic atrial fibrillation and aortic aneurysm.

Immunogen :

Recombinant fusion protein containing a sequence corresponding to amino acids 20-107 of mouse MMP9.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:1,000-1:10,000