Metadherin Recombinant Rabbit Monoclonal Antibody (4V0R6) | Invitrogen MA5-55287 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Metadherin Recombinant Rabbit Monoclonal Antibody (4V0R6)

catalog :

MA5-55287

quantity :

100 uL

price :

US 419.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

4V0R6

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Metadherin Recombinant Rabbit Monoclonal Antibody (4V0R6)

Catalog # :

MA5-55287

Quantity :

100 uL

Price :

US 419.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human, Mouse, Rat

Clone :

4V0R6

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 308-407 of human LYRIC/AEG1.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

2610103J23Rik; 3D3; 3D3/Lyric; AEG1; AEG-1; astrocyte elevated gene 1; astrocyte elevated gene-1 protein; AV353288; D8Bwg1112e; LYRIC; LYRIC/ MTDH; LYRIC/3D3; lysine-rich CEACAM1 co-isolated protein; Metadherin; metastasis adhesion protein; MTDH; Protein LYRIC