ALAS1 Recombinant Rabbit Monoclonal Antibody (23GB3190) | Invitrogen MA5-53358 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ALAS1 Recombinant Rabbit Monoclonal Antibody (23GB3190)

catalog :

MA5-53358

quantity :

100 uL

price :

US 539.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

23GB3190

reactivity :

human, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

ALAS1 Recombinant Rabbit Monoclonal Antibody (23GB3190)

Catalog # :

MA5-53358

Quantity :

100 uL

Price :

US 539.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Western Blot: 1:1,000-1:5,000

Species :

Human, Rat

Clone :

23GB3190

Isotype :

IgG

Storage :

-20 C

Description :

ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5' phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.

Immunogen :

A synthetic peptide of human Alas1 (600-640AA).

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000-1:5,000

Aliases :

5'-aminolevulinate synthase 1; 5-aminolevulinate synthase 1; 5-aminolevulinate synthase, nonspecific, mitochondrial; 5-aminolevulinic acid synthase 1; ALAS; ALA-S; ALAS1; Alas-1; ALAS3; ALASH; Alas-h; ALAS-N; aminolevulinate synthase H; aminolevulinate, delta-, synthase 1; aminolevulinic acid synthase 1; delta-ALA synthase 1; delta-ALA synthetase; delta-aminolevulinate synthase 1; MIG4; migration-inducing protein 4; OK/SW-cl.121; succinyl-CoA: glycine C-succinyl transferase