This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
AHR Recombinant Rabbit Monoclonal Antibody (23GB1635)
catalog :
MA5-53351
quantity :
20 uL
price :
US 199.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
23GB1635
reactivity :
human
application :
western blot, immunocytochemistry, flow cytometry
product information
Product Type :
Antibody
Product Name :
AHR Recombinant Rabbit Monoclonal Antibody (23GB1635)
Catalog # :
MA5-53351
Quantity :
20 uL
Price :
US 199.00
Clonality :
Recombinant Monoclonal
Purity :
Affinity chromatography
Host :
Rabbit
Reactivity :
Human
Applications :
Flow Cytometry: 1:2,000, Immunocytochemistry: 1:1,000, Western Blot: 1:1,000-1:5,000
Species :
Human
Clone :
23GB1635
Isotype :
IgG
Storage :
-20 C
Description :
AHR (Ah Receptor) belongs to a family of proteins comprised of its dimerization partner ARNT (HIF-1 Beta) and the Drosophila proteins PER and SIM. AHR contains an N-terminal sequence of approximately 200 amino acids termed the PAS domain. AHR, found in a variety of tissues, binds to a specific DNA enhancer sequence and initiates transcription of the mRNA for the cytochrome P-450 (CYPIA1) gene. The gene for AHR encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450, and its ligands included a variety of aromatic hydrocarbons. AHR is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. The known ligands for AHR are foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for AHR. Studies indicate that in non-ligand activated cells, AHR is found complexed with HSP90 predominantly in the cytoplasm. Upon binding to an agonist, the ligand-activated AhR is believed to transform to a nuclear, DNA binding form, and this transformation process appears to involve dissociation of HSP90 from AhR followed by formation of a heterodimer with AhR nuclear translocator protein (Arnt). Diseases associated with AHR include eosinophilic fasciitis and seborrheic dermatitis.
Immunogen :
A synthesized peptide derived from human AhR (724-780AA).
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 1:2,000, Immunocytochemistry: 1:1,000, Western Blot: 1:1,000-1:5,000
Aliases :
Ah; Ah receptor; Ahh; Ahr; Ahre; AH-receptor; aromatic hydrocarbon receptor; aryl hydrocarbon receptor; aryl-hydrocarbon receptor; bHLHe76; Class E basic helix-loop-helix protein 76; dioxin receptor; In
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA