SOCS3 Recombinant Rabbit Monoclonal Antibody (10T9C2) | Invitrogen MA5-51240 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SOCS3 Recombinant Rabbit Monoclonal Antibody (10T9C2)

catalog :

MA5-51240

quantity :

100 uL

price :

US 424.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

10T9C2

reactivity :

human, mouse

application :

western blot, ELISA

product information

Product Type :

Antibody

Product Name :

SOCS3 Recombinant Rabbit Monoclonal Antibody (10T9C2)

Catalog # :

MA5-51240

Quantity :

100 uL

Price :

US 424.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

ELISA: 1 ug/mL, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse

Clone :

10T9C2

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 126-225 of human SOCS3 (NP_003946.3).

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:1,000-1:5,000

Aliases :

ATOD4; CIS3; CIS-3; Cish3; cytokine inducible SH2-containing protein 3; cytokine-inducible SH2 protein 3; E2a-Pbx1 target gene in fibroblasts 10; Ef10; EF-10; MGC71791; Protein EF-10; Socs3; Socs-3; SSI3; SSI-3; STAT-induced STAT inhibitor 3; Suppressor of cytokine signaling 3