MPZ Monoclonal Antibody (C13) | Invitrogen MA5-51125 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

MPZ Monoclonal Antibody (C13)

catalog :

MA5-51125

quantity :

200 uL

price :

US 373.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C13

reactivity :

human, mouse, rat, pigs

application :

western blot

product information

Product Type :

Antibody

Product Name :

MPZ Monoclonal Antibody (C13)

Catalog # :

MA5-51125

Quantity :

200 uL

Price :

US 373.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human, Mouse, Porcine, Rat

Applications :

Western Blot: 0.002-2 ug/mL

Species :

Human, Mouse, Porcine, Rat

Clone :

C13

Isotype :

IgG3, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Zero, also known as myelin protein zero (MPZ) is a Type 1 integral membrane glycoprotein that mediates adhesion of spiraling wraps of the myelin sheath in order to ensure stable synaptic transmission. Zero protein encompasses approximately 50% of total protein in the sheath scaffolding in contribution to structural integrity of peripheral myelin. Zero guides the compact myelin wrapping process through glycine zipper packing interface-dependent dimer and tetramer formation. Mutations (e.g. G134R) can abrogate multimer formation, cause demyelinating neuropathies, and are known to contribute to conditions that include Charcot-Marie-Tooth disease. Zero cytoplasmic domain undergoes serine and tyrosine phosphorylation, which appears to be prevalent during peak nerve myelination. Zero transcript is moderate in brain, abundant in thymus and most abundant in white matter of the CNS.

Immunogen :

Recombinant Human MPZ protein, Ile30-Lys248 (Accession #P25189)

Format :

Liquid

Applications w/Dilutions :

Western Blot: 0.002-2 ug/mL

Aliases :

Charcot-Marie-Tooth neuropathy 1B; CHM; CMT1; CMT1B; CMT2I; CMT2J; CMT4E; CMTDI3; CMTDID; DSS; HMSNIB; MPP; MPZ; Myelin peripheral protein; myelin protein P0; Myelin protein zero; myelin protein zero (Charcot-Marie-Tooth neuropathy 1B); P0; P-zero