IDO Monoclonal Antibody (C14) | Invitrogen MA5-50873 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IDO Monoclonal Antibody (C14)

catalog :

MA5-50873

quantity :

200 uL

price :

US 393.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

C14

reactivity :

human, pigs

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

IDO Monoclonal Antibody (C14)

Catalog # :

MA5-50873

Quantity :

200 uL

Price :

US 393.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Human, Porcine

Applications :

Immunocytochemistry: 5-30 ug/mL, Immunohistochemistry (Paraffin): 5-30 ug/mL, Western Blot: 0.01-2 ug/mL

Species :

Human, Porcine

Clone :

C14

Isotype :

IgG2a, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

IDO1 is an intracellular heme-containing enzyme that catalyzes the oxidative cleavage of the indole ring of several important regulatory molecules like tryptophan, serotonin, and melatonin. By doing this, IDO1 initiates the production of biologically active metabolites, commonly referred to as kynurenines. IDO1 is widely expressed in a variety of human tissues as well as in macrophages and dendritic cells (DCs). In inflammation, interferons (IFNs) act on specific receptors to trigger IDO1 induction. The production of IFN-gamma and induction of IDO1 represent important antimicrobial mechanisms. Degradation and depletion of tryptophan by IDO1 inhibits the growth of viruses, bacteria and parasites. Furthermore, IDO1 plays a complex and crucial role in immunoregulation during infection, pregnancy, autoimmunity, transplantation, and neoplasia.

Immunogen :

Recombinant Human IDO protein, Ala2-Gly403 (Accession #P14902)

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 5-30 ug/mL, Immunohistochemistry (Paraffin): 5-30 ug/mL, Western Blot: 0.01-2 ug/mL

Aliases :

EC 1.13.11.52; IDO; IDO1; IDO-1; INDO; indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine; indoleamine 2,3-dioxygenase 1; indoleamine 23-dioxygenase; Indoleamine-2; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase