PSME2 Recombinant Rabbit Monoclonal Antibody (PSH0-10) | Invitrogen MA5-50771 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PSME2 Recombinant Rabbit Monoclonal Antibody (PSH0-10)

catalog :

MA5-50771

quantity :

100 uL

price :

US 470.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

PSH0-10

The same clone is also sold as:

Novus Biologicals: NBP3-32868

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

PSME2 Recombinant Rabbit Monoclonal Antibody (PSH0-10)

Catalog # :

MA5-50771

Quantity :

100 uL

Price :

US 470.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:500-1:1,000, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:4,000, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse, Rat

Clone :

PSH0-10

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Others are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (approximately 31), barrel-shaped molecular machine with an apparent molecular weight of approximately 2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelman's syndrome, and Liddle syndrome.

Immunogen :

Recombinant protein within human aa 2-239/239.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:500-1:1,000, Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:4,000, Western Blot: 1:1,000-1:5,000

Aliases :

11S regulator complex beta subunit; 11S regulator complex subunit beta; AA589371; Activator of multicatalytic protease subunit 2; AI788882; cell migration-inducing protein 22; MCP activator, 31-kD subunit; PA28b; Pa28b1; PA28beta; protease (prosome, macropain) 28 subunit, beta; proteasome (prosome, macropain) 28 subunit, beta; proteasome (prosome, macropain) activator subunit 2; proteasome (prosome, macropain) activator subunit 2 (PA28 beta); proteasome activator 28 subunit beta; proteasome activator 28-beta; proteasome activator complex subunit 2; proteasome activator hPA28 subunit beta; proteasome activator subunit 2; Psme2; REGbeta; REG-beta