TBK1 Recombinant Rabbit Monoclonal Antibody (14D10) | Invitrogen MA5-50051 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TBK1 Recombinant Rabbit Monoclonal Antibody (14D10)

catalog :

MA5-50051

quantity :

100 uL

price :

US 414.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

14D10

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

TBK1 Recombinant Rabbit Monoclonal Antibody (14D10)

Catalog # :

MA5-50051

Quantity :

100 uL

Price :

US 414.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human

Clone :

14D10

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

TBK1 serine/threonine kinase is a member of the IKK family and is involved in NF-kappa B activation and IRF3 signaling. TBK1 is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-KB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-KB is associated with IKB proteins in the cell cytoplasm, which inhibit NF-KB activity. Phosphorylation of I-KB by IKB kinase (IKK) complex leads to degradation of I-KB and activation of NF-KB. The IKK complex contains IKKa, IKK beta, and IKKK. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-KB-activating kinase), and T2K. NAK/TBK1 activates IKK beta through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

Immunogen :

A synthesized peptide derived from human TBK1

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

1200008B05Rik; AI462036; AW048562; FLJ11330; FTDALS4; NAK; NF-kappa-B-activating kinase; NF-kB-activating kinase; serine/threonine protein kinase TBK1; serine/threonine-protein kinase TBK1; T2K; TANK binding kinase 1; TANK-binding kinase 1; tbk; TBK1