Occludin Recombinant Rabbit Monoclonal Antibody (8H8) | Invitrogen MA5-49990 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Occludin Recombinant Rabbit Monoclonal Antibody (8H8)

catalog :

MA5-49990

quantity :

100 uL

price :

US 414.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

8H8

reactivity :

human

application :

immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Occludin Recombinant Rabbit Monoclonal Antibody (8H8)

Catalog # :

MA5-49990

Quantity :

100 uL

Price :

US 414.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human

Clone :

8H8

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

Occludin is a 65 kDa protein that can exist in a variety of phosphorylated forms, ranging up to approximately 82 kDa. Occludin is thought to be involved in regulating both the localization and the function of occludin. Polyunsaturated fatty acids are known to up-regulate occludin expression, increasing the transendothelial cell resistance and reducing the cellular permeability to large molecules. The level of occludin varies greatly depending on tissue; in brain tissue, occludin is highly and continuously expressed at cell-cell contact sites, whereas non-neural tissues show lower expression and discontinuous distribution. Overall structural features of the occludin protein are highly conserved in all the species examined. Under-expression of tight junction proteins, including occludin, is a key molecular abnormality responsible for the increased permeability of tumor endothelial tight junctions, which contributes to brain tumor edemas.

Immunogen :

A synthesized peptide derived from human OCLN

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

AI503564; BLCPMG; Occludin; occludin 1B; Ocl; Ocln; phosphatase 1, regulatory subunit 115; PPP1R115; tight junction protein occludin; tight junction structural protein