Claudin 18 Recombinant Human Monoclonal Antibody (25E3) | Invitrogen MA5-49964 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Claudin 18 Recombinant Human Monoclonal Antibody (25E3)

catalog :

MA5-49964

quantity :

100 uL

price :

US 414.00

clonality :

recombinant

host :

human

conjugate :

nonconjugated

clone name :

2.50E+04

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

Claudin 18 Recombinant Human Monoclonal Antibody (25E3)

Catalog # :

MA5-49964

Quantity :

100 uL

Price :

US 414.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Human

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:50-1:200

Species :

Human

Clone :

2.50E+04

Isotype :

IgG1

Storage :

-20 C or -80 C if preferred

Description :

Claudin-18 is a tight junction protein expressed as lung-and stomach-specific isoforms which are generated by alternative splicing of the claudin-18 gene. The lung-specific form is a downstream target gene regulated by the T/EBP/NKX2.1 transcription factor. A splice variant lacking the C-terminal cytoplasmic domain also exists in mouse, but has not been confirmed in human. Human claudin-18 demonstrates 88% amino acid sequence identity to the mouse protein. Immunohistochemical studies have demonstrated complete membrane localization of claudin-18 in lung and stomach epithelial cells, while electron microscopy has shown that it is concentrated in the cell-cell borders of these cells. These features suggest a potentially important role for claudin-18 in the structure and function of tight junctions in the lung and stomach. Claudin-18 expression has also been reported in the inner ear.

Immunogen :

Recombinant Human CLDN18 protein

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1:50-1:200

Aliases :

claudin 18; claudin 18-like; claudin-18; CLDN18; SFTA5; SFTPJ; surfactant associated 5; surfactant associated protein J; surfactant, pulmonary associated protein J; UNQ778/PRO1572