LDLR Recombinant Rabbit Monoclonal Antibody (2B10) | Invitrogen MA5-49804 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

LDLR Recombinant Rabbit Monoclonal Antibody (2B10)

catalog :

MA5-49804

quantity :

100 uL

price :

US 414.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

2B10

reactivity :

human

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

LDLR Recombinant Rabbit Monoclonal Antibody (2B10)

Catalog # :

MA5-49804

Quantity :

100 uL

Price :

US 414.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:20-1:200, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:50-1:200

Species :

Human

Clone :

2B10

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

Immunogen :

A synthesized peptide derived from human LDL Receptor

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1:20-1:200, Immunocytochemistry: 1:20-1:200, Immunohistochemistry (Paraffin): 1:50-1:200

Aliases :

FH; FHC; Hlb301; I79_005860; LDL receptor; LDLA; LDLCQ2; LDLR; ldl-r; LDLRA; low density lipoprotein receptor; low density lipoprotein receptor protein; low-density lipoprotein receptor; low-density lipoprotein receptor class A domain-containing protein 3