HLA-C Monoclonal Antibody (3C9E11) | Invitrogen MA5-48489 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HLA-C Monoclonal Antibody (3C9E11)

catalog :

MA5-48489

quantity :

100 µg

price :

US 484

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3C9E11

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

HLA-C Monoclonal Antibody (3C9E11)

Catalog # :

MA5-48489

Quantity :

100 µg

Price :

US 484

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

ELISA: 1:10,000, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:500-1:2,000

Species :

Human, Mouse

Clone :

3C9E11

Isotype :

IgG1

Storage :

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Description :

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described. HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

Immunogen :

Purified recombinant fragment of human HLA-C (AA: 25-308) expressed in E. Coli.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:10,000, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:500-1:2,000

Aliases :

alpha chain of MHC class II; D6S204; HLA C; HLA class I histocompatibility antigen C alpha chain; HLA class I histocompatibility antigen Cw-1 alpha chain; HLA class I histocompatibility antigen, C alpha chain; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLA class I histocompatibility antigen, Cw-15 alpha chain; HLA class I histocompatibility antigen, Cw-18 alpha chain; HLAC; HLA-C; HLA-C alpha chain; HLA-C alpha chain (HLA-Cw*15v); HLA-C alpha chain for Cw*18GB; HLA-C alpha-chain; HLA-C antigen; HLA-Cw; HLA-Cw*04GB; HLA-Cw*1702; HLA-Cw*18GB; HLA-Cw-1503; HLA-JY3; HLC-C; Human leukocyte antigen C; human leukocyte antigen-C alpha chain; leukocyte antigen C; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC; MHC clas I antigen; MHC class 1 antigen; MHC Class I antigen; MHC class I antigen Cw*15; MHC class I antigen Cw*18; MHC class I antigen heavy chain HLA-C; MHC class I histocompatibility antigen; MHC class I molecule; MHC class II antigen; PSORS1; surface antigen; truncated MHC class I antigen