EB1/EB2/EB3 Monoclonal Antibody (KT65) | Invitrogen MA5-47713 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EB1/EB2/EB3 Monoclonal Antibody (KT65)

catalog :

MA5-47713

quantity :

100 uL

price :

US 454.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

KT65

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

EB1/EB2/EB3 Monoclonal Antibody (KT65)

Catalog # :

MA5-47713

Quantity :

100 uL

Price :

US 454.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Rat

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:50, Western Blot: 1:500

Species :

Human, Mouse, Rat

Clone :

KT65

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The microtubule (MT) plus-end is a crucial site for the regulation of MT dynamics and interactions by several groups of plus-end tracking proteins (+TIPs). These +TIPs form comet-like accumulations at the plus ends of MTs to regulate MT dynamics and interactions with organelles and macromolecular complexes. The +TIPs include diverse groups of proteins, such as motor and nonmotor proteins, MT polymerases and depolymerases as well as various regulatory and adaptor proteins. The CLIP-associated protein (CLASP) family includes CLASP1 and CLASP2 proteins, which are expressed as long (alpha) and short (beta) isoforms. Thse +TIPs conatin an N-terminal TOG domain, multiple TOG-like domains, and a basic and serine-rich motif (SxIP). The TOG domain facilitates interaction with tubulin dimers, while the SxIP motif promotes interaciton with EB1 and MTs. A C-terminal domain is involved in interaction with CLIPs, as well as several other proteins. CLASPs are MT stabilizing fators that localize to mitotic spindles, kinetochores, and the midbody. CLASPs are important for cell division, and may regulate cell migration and neuronal growth cone motility.

Immunogen :

Clone KT65 was generated from a GST fusion protein containing amino acids from the C-terminal region mouse EB1. This sequence is highly conserved in human and rat EB1.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50, Western Blot: 1:500

Aliases :

APC; Microtubule RP/EB