PKC theta Monoclonal Antibody (M217) | Invitrogen MA5-47677 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PKC theta Monoclonal Antibody (M217)

catalog :

MA5-47677

quantity :

100 uL

price :

US 530.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M217

The same clone is also sold as:

Abcam: ab76197

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

PKC theta Monoclonal Antibody (M217)

Catalog # :

MA5-47677

Quantity :

100 uL

Price :

US 530.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100, Western Blot: 1:1000

Species :

Human, Mouse, Rat

Clone :

M217

Isotype :

IgG2a

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Protein Kinase C (PKC) isoforms are serine/threonine kinases involved in signal transduction pathways that govern a wide range of physiological processes including differentiation, proliferation, gene expression, brain function, membrane transport and the organization of cytoskeletal and extracellular matrix proteins. Increasing evidence from studies using in vitro and in vivo systems points to PKC as a key regulator of critical cell cycle transitions, including cell cycle entry and exit and the G1 and G2 checkpoints. PKC-mediated control of these transitions can be negative or positive, depending on the timing of PKC activation during the cell cycle and on the specific PKC isozymes involve. There have been at least 12 different PKC isoforms identified in humans to date, including alpha, beta I, beta II, gamma, delta, epsilon, zeta, eta, theta, iota, lambda, and mu. The different PKC isoforms vary in structure, subcellular localization, tissue distribution and response to extracellular signals. PKC beta II has been shown to be expressed, in part, in cardiac muscle, intestinal epithelium, kidney and pancreas. PKC beta II has been shown to be involved in cell cycle progression and cancer proliferation.

Immunogen :

Clone (M217) was generated from a recombinant mouse PKC theta protein that included amino acids residues in the N-terminal region. This sequence is conserved in human and rat PKC theta, and has low homology to other PKC family members.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Western Blot: 1:1000

Aliases :

A130035A12Rik; AW494342; EC 2.7.11.13; kinase nPKC-theta; KPCT; MGC126514; MGC141919; nPKC-theta; PKC theta; PKC-0; Pkcq; PKCtheta; PKC-theta; PRKCQ; PRKCT; protein kinase C theta; protein kinase C theta type; protein kinase C, theta; RP11-563J2.1; si:ch211-239o15.1