CD244 (2B4) Monoclonal Antibody (M085) | Invitrogen MA5-47660 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD244 (2B4) Monoclonal Antibody (M085)

catalog :

MA5-47660

quantity :

100 uL

price :

US 530.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M085

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

CD244 (2B4) Monoclonal Antibody (M085)

Catalog # :

MA5-47660

Quantity :

100 uL

Price :

US 530.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Immunocytochemistry: 1:200, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Species :

Human

Clone :

M085

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

CD244 (Natural killer (NK) cell receptor 2B4/SLAMF4) is an Ig superfamily signaling lymphocyte activation molecule (SLAM) receptor. Like all SLAM family receptors, it has an extracellular segment with two immunoglobulin (Ig)-like domains, and a cytoplasmic domain containing four immunoreceptor tyrosine-based switch motifs. CD244 does not act as a selfligand similar to other SLAM family receptors. It binds CD48, a transmembrane receptor ubiquitously expressed on hematopoietic cells. CD244 activity is controlled by the presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Downstream signaling involves predominantly VAV1, and, to a lesser degree, INPP5D/SHIP1 and CBL. Activation of CD244 stimulates NK cell cytotoxicity, production of IFN-gamma and granule exocytosis. CD244 is involved in the regulation of CD8+ T-cell proliferation, and inhibits inflammatory responses in dendritic cells (DCs). In cancers, CD244 shows increased expression in intratumoral DCs and myeloid suppressor cells, and anti-CD244 therapies may increase infiltrating T-cells and impair tumor growth.

Immunogen :

Clone (M085) was generated from a recombinant protein that included the extracellular region of human CD244 protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunocytochemistry: 1:200, Immunoprecipitation: 1:100, Western Blot: 1:1,000

Aliases :

NKR2B4; SLAMF4