Phospho-beta Dystroglycan (Tyr892) Monoclonal Antibody (M117) | Invitrogen MA5-47624 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-beta Dystroglycan (Tyr892) Monoclonal Antibody (M117)

catalog :

MA5-47624

quantity :

100 uL

price :

US 520.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M117

The same clone is also sold as:

Abcam: ab29037

reactivity :

human, mouse, rat

application :

western blot

product information

Product Type :

Antibody

Product Name :

Phospho-beta Dystroglycan (Tyr892) Monoclonal Antibody (M117)

Catalog # :

MA5-47624

Quantity :

100 uL

Price :

US 520.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

M117

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.

Immunogen :

Clone (M117) was generated from a synthetic peptide (coupled to KLH) corresponding to amino acid residues around tyrosine 892 of human dystroglycan. This peptide sequence has high homology to the conserved tyrosine site in rat and mouse dystroglycan.

Format :

Liquid

Applications w/Dilutions :

Western Blot: 1:1,000

Aliases :

156DAG; A3a; AGRNR; Alpha-DG; Alpha-dystroglycan; Beta-DG; Beta-dystroglycan; D9Wsu13e; DAG; DAG1; Dag-1; DG; Dp427; Dp71; dystroglycan; dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1; MDDGA9; MDDGC7; MDDGC9