TDP-43 Monoclonal Antibody (3H8) | Invitrogen MA5-47420 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TDP-43 Monoclonal Antibody (3H8)

catalog :

MA5-47420

quantity :

100 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3H8

The same clone is also sold as:

Novus Biologicals: NBP1-92695

reactivity :

human, mouse, rat, bovine, pigs , domestic horse

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

TDP-43 Monoclonal Antibody (3H8)

Catalog # :

MA5-47420

Quantity :

100 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Protein A/G

Host :

Mouse

Reactivity :

Bovine, Equine, Human, Mouse, Porcine, Rat

Applications :

Immunocytochemistry: 1:2,000-1:5,000, Immunohistochemistry (PFA fixed): 1:2,000-1:5,000, Western Blot: 1:5,000

Species :

Bovine, Equine, Human, Mouse, Porcine, Rat

Clone :

3H8

Isotype :

IgG1, kappa

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Immunogen :

Full length recombinant human TDP43 expressed in and purified from E. coli.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:2,000-1:5,000, Immunohistochemistry (PFA fixed): 1:2,000-1:5,000, Western Blot: 1:5,000

Aliases :

1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg