GAD65/GAD67 Recombinant Rabbit Monoclonal Antibody (HL1181) | Invitrogen MA5-46950 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

GAD65/GAD67 Recombinant Rabbit Monoclonal Antibody (HL1181)

catalog :

MA5-46950

quantity :

100 uL

price :

US 444.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

HL1181

reactivity :

human, mouse, rat, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

GAD65/GAD67 Recombinant Rabbit Monoclonal Antibody (HL1181)

Catalog # :

MA5-46950

Quantity :

100 uL

Price :

US 444.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat, Zebrafish

Applications :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:500-1:3,000

Species :

Human, Mouse, Rat, Zebrafish

Clone :

HL1181

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA ( gamma-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67: the predominant GAD-67 form and the minor GAD-25 form.

Immunogen :

Recombinant protein encompassing a sequence within the C-terminus region of human GAD65. The exact sequence is proprietary.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: Assay-dependent, Immunohistochemistry (Paraffin): Assay-dependent, Western Blot: 1:500-1:3,000

Aliases :

6330404F12Rik; 65 kDa glutamic acid decarboxylase; 67 kDa glutamic acid decarboxylase; CPSQ1; EC 4.1.1.15; EP10; FLJ45882; GAD; GAD 1; GAD 2; GAD 65; GAD 67; GAD(65); GAD1; Gad-1; Gad2; Gad-2; GAD25; GAD44; Gad65; GAD-65; GAD67; GAD-67; Glutamate decarboxylase 1; Glutamate decarboxylase 1 (brain); glutamate decarboxylase 1 (brain, 67kDa); glutamate decarboxylase 1 variant GAD67NT; glutamate decarboxylase 2; Glutamate decarboxylase 2 (islet); glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); glutamate decarboxylase 65 kDa isoform; Glutamate decarboxylase 67 kDa isoform; GLUTAMATE DECARBOXYLASE, 67 KD ISOFORM (GAD-67) (67 KD GLUTAMIC ACID DECARBOXYLASE); Glutamate decarboxylase-2 (pancreas); glutamic acid decarboxylase; glutamic acid decarboxylase 1; glutamic acid decarboxylase 2; glutamic acid decarboxylase 65; SCP