Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AH36), FITC | Invitrogen MA5-45934 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AH36), FITC

catalog :

MA5-45934

quantity :

100 ug

price :

US 470.00

clonality :

monoclonal

host :

domestic rabbit

conjugate :

FITC

clone name :

AH36

The same clone is also sold as:

StressMarq Biosciences: SMC-601
Novus Biologicals: NBP3-18265

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, dot blot

product information

Product Type :

Antibody

Product Name :

Phospho-Tau (Ser202, Thr205) Monoclonal Antibody (AH36), FITC

Catalog # :

MA5-45934

Quantity :

100 ug

Price :

US 470.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Dot Blot: Assay-dependent, ELISA: Assay-dependent, Immunocytochemistry: 1:500, Immunohistochemistry: 1:500, Western Blot: 1:500

Species :

Human, Mouse

Clone :

AH36

Isotype :

IgG

Storage :

4 C, store in dark

Description :

Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton while the longer isoforms may preferentially play a role in its stabilization. In its hyper-phosphorylated form, Tau is the major component of paired helical filaments (PHF), the building block of neurofibrillary lesions in Alzheimer's diseases (AD) brain. Hyper-phosphorylation impairs the microtubule binding function of Tau, resulting in the destabilization of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Numerous serine/threonine kinases phosphorylate Tau, including GSK-3beta, protein kinase A (PKA), cyclin-dependent kinase 5 (cdk5) and casein kinase II. Hyper-phosphorylated Tau is found in neurofibrillary lesions in a range and other central nervous system disorders such as Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Immunogen :

Synthetic peptide of Human Phospho Tau (Ser202/Thr205)

Format :

Liquid

Applications w/Dilutions :

Dot Blot: Assay-dependent, ELISA: Assay-dependent, Immunocytochemistry: 1:500, Immunohistochemistry: 1:500, Western Blot: 1:500

Aliases :

AI413597; AW045860; DDPAC; FLJ31424; FTDP17; FTDP-17; G protein beta1/gamma2 subunit-interacting factor 1; map tau; Mapt; MAPTL; MGC138549; microtubule associated protein tau; microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; microtubules; MSTD; Mtapt; MTBT1; MTBT2; Neurofibrillary tangle protein; neurofibrillary tangles; Neuronal Marker; paired helical filament-tau; PHFtau; PHF-tau; PPND; PPP1R103; protein phosphatase 1, regulatory subunit 103; pTau; RNPTAU; Tau; Tau microtubule-associated protein; tau protein; Tau-4; Tau5; Unknown (protein for MGC:134287)